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26 Cards in this Set
- Front
- Back
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primary disease associated with EBV?
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. Infectious mononucleosis
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classic triad of Infectious mononucleosis?
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a. lymphadenopathy (cervical)
b. pharyngitis c. fever (up to 1040; may last 2 weeks. |
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aside from the classic triad of infectious mono, what are 2 distinguishing characteristics of the disease?
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a. “atypical”, large lymphocytes;
b. “heterophile” antibodies (react with sheep, horse, bovine RBC’s). |
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What is mono most commonly misdiagnosed as what?
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Strep throat
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splenomegaly and rash are additional signs of what problem?
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Mono
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A pt has mono, but gets diagnosed with strep throat...later they end up with a rash..what happened?
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they were given ampicillin for the tx of strep and had a rxn
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90% of pts with mono are positive for what? (this shows that EBV was the cause)
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Heterophile Ab
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You suspect a pt to have mono.
They are heterophile + cause? |
EBV
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You suspect a pt to have mono.
They are heterophile - They have lymphocytosis or >10% atypcial What is your next question? |
EBV IgM +/-?
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You suspect a pt to have mono.
They are heterophile - They have lymphocytosis or >10% atypcial They are Negative for EBV IgM What is your next question? |
CMV IgM +/-?
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You suspect a pt to have mono.
They are heterophile - They have lymphocytosis or >10% atypcial They are Negative for EBV IgM They are Negative for CMV IgM What was the cause? |
Toxoplamosis
Hepatitis A,B,C or human herpes virus 6 |
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EBV vs CMV
rash |
EBV: has rash
CMV: no rash |
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After oral epithelial cells are infected, what cell then is infected? Is this productive or non-productive?
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B-cell gets infected
this is non-preductive |
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what cell is markedly increased in mono?
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B-cells
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after a large proliferation in B-cells, what does the body do in response?
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activates CD8 T-cells to attack the B-cells
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what are atypical lymphocytes?
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activated CD8 T-cells
sent to kill the wildly proliferative B-cells also known as Downey Cells |
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transmission of mono occurs from what?
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saliva transmission...
aka SUCKING FACE WITH RANDO BIDDIES. |
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this virus can be a co-factor of Burkitt's Lymphoma, Hodgkin's Lymphoma, nasopharyngeal carcinoma, AIDS-associated & post-transplant lymphomas
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EBV
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Tx for mono? why?
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supportive
remember that it is dormant in replicating B-cells, so we can't really attack it with anti-herpesviral drugs |
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most people will have CMV during their lifetime. When will these be a problem?
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prenatal, neonatal, or shortly postnatal.
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Blueberry muffin rash=
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Cytomegalovirus
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CMV may have no symptoms in a baby, but what might they lead to later in life?
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ADHD and learning defects
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heterophile negative mononucleousis is normally caused by?
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CMV
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in immunosuppressed pts, what is a likely symptom associated with CMV?
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retinitis
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Transmission of CMV? 5
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resp droplet
fecal-oral transplacental breast milk STD |
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Owl's eye cells=
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CMV
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