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8 Cards in this Set
- Front
- Back
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What are some of the clinical uses of immunosuppressives?
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Solid Organ and Bone Marrow (BM) Transplantation
Prevention of allograft rejection Graft-versus-host disease (GVHD) Isoimmune disorders Autoimmune diseases |
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in general you have to use immunosuppressives for long periods of time (even life long), so what does this put them at risks for?
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Higher risks for infections and cancer
opportunistic infections (protozoal, bacterial, fungal, viral) |
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This drug has serious nephrotox and can look like rejection if used in kidney transplant
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Cyclosporine
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the MOA of tacrolimus is similar to Cyclosporine, but differs in one way...what is it?
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Tacrolimis and Cyclosporine bind to different cytoplasmic proteins
Tacrolimus: FKBP Cyclosporine: Cyclophilin they both then bind to calcineurin to inhibit IL2 proliferation |
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2 MAJOR must know tox for Cyclosporine?
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nephrotox and HYPERKALEMIA (commonly occurs, reduced efficiency of unrinary K excretion, can be potentially life threating when used with an ACE INHIBITOR, which decreases aldosterone release)
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What drug can treat ongoing rejection at high doses?
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Azathioprine
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What immunosuppresant drug is inactivated by xanthine oxidase? what drug will make you have to reduce the dose? What anti-cancer drug shares this property?
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Azathioprine
Allopurinol 6MP |
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What immunosuppressive is used during acute rejection episodes? 3
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ATG
Muromonab-CD3 (OKT3) Daclizumab |
