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10 Cards in this Set
- Front
- Back
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Pure Manic Episode |
Euphoric Mania |
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Hypomanic Episode |
Hypomania |
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Major Depressive Episode |
Depression |
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Drug Therapy |
- Mood stabilizers - Antipsychotics - Antidepressants |
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Mood Stabilizers |
Lithium, Divalpoex sodium (Valproate), Carbamazepine (Tegretol) |
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Lithium MOA |
Altered distribution of certain ions (Ca, NaMg), altered synthesis and release of NE, serotonin and dopamine; effectis on second messengers (e.g. Cyclic AMP) |
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Lithium Pharmacokinetics |
Well absorbed PO, even distribution Short half-life Excreted by kidneys Highly toxic |
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Lithium Adverse Effects at Toxic Levels |
When mild= fine hand tremor, GI upset, thirst, muscle weakness Need plasma level monitoring |
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Lithium Adverse Effects at Therapeutic Levels |
Tremor, polyuria, renal toxicity, goiter and hypothyroidism, teratogenesis |
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Lithium Drug Interactions |
- Diuretics: promote Na loss, increase risk of Lithium toxicity - NSAIDs: can increase lithium levels by increase renal absorption - Anticholinergic drugs: urinary hesitancy |
