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10 Cards in this Set
- Front
- Back
Daclizumab
(Zenapax) |
-humanized monoclonal ab to IL-2R alpha
-prophylaxis of renal transplant rejection -binds to IL-2 receptor on T-helper cells |
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Basiliximab
(Simulect) |
-humanized monoclonal ab to IL-2R alpha
-renal, lier transplant rejection prophylaxis -blocks binding of IL-2 to the IL-2R alpha subunit |
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Abciximab
(ReoPro) |
-humanized Fab fragment that binds to glycoprotein IIb/IIIa receptor of platelets blocking aggregation
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Infliximab
(Remicade) |
-humanized monoclonal ab to TNF-alpha
I:Crohn's disease, RA -binds and neuralizes TNF-alpha |
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Adalimumab
(HUMIRA) |
-true human monoclonal to TNF-alpha
I:RA -prefilled syringe w/plastic wings |
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Rituximab
(Rituxan) |
-humanized monoclonal ab against CD-20
I:non-Hodgkin's lymphoma(relapsed or refractory),chronic lymhocytic leukemia, RA, macroglobulinemi, Walenstroms -1st mab approved for cancer. CD20 is early signalling for cancer |
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Alemtuzumab
(Campath) |
-humanized mab against CD-20
I:B-cell chronic lymphocytic leukemia -watch CD4+ count |
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Efalizumab
(Raptiva) |
-humanized mab against CD11a
I:plaque psoriasis (mod/severe) -blocks binding to ICAM-1 required for cell commumication |
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Trastuzumab
(Herceptin) |
-humanized mab against HER-2
I:breast cancer -some pts have anaphylactic reactions |
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Cetuximab
(Erbitux) |
-chimeric mab to EGFR
I:colorectral cancer,squamous cell cacinoma -Martha's drug, requires +EGFR expression |