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51 Cards in this Set

  • Front
  • Back
HIV resistant individuals have what
a rare form of a gene
what does the rare form of the gene do in HIV resistant people
it codes for an immune cell surface protein
what is the immune cell surface protein that cods genes for hiv resisitant people
CCR5
what is hiv main binding site
CD4
what is the coreceptor required for HIV
CCR5
what do individuals who are hiv resisistant lack in regards to CD4 and CCR5
they do not have a binding site for CCR5
why is this breakthrough with HIV important
CD4 inhibiting is dangerous. If we can inhibit CCR5, it would be a safer target and we can develop drugs that mask CCR5 and block entry.
what is maraviroc
a CCR5 inhibitor that has been approved for treatment of HIV
what is crucial to the function of an organism
cell to cell recognition
what 2 main reasons is cell to cell recognition important
it sorts cells into tissue and organs in embryo
the basis for rejection in immunity
how do cells recognize one another
binding molecules
what are the binding molecules on cells containing
carbohydrates
where are the carbohydrates that allow binding molecules to recognize other cells located
extracellular plasma membrane
describe membrane carbohydrates
short branched chains of fewer than 15 units
what type of bonding occurs in between carbohydrate molecules and lipids
covalent
carbohydrate molecules covalently bonded to lipids are called
glycolipids
most carbs are bound covalently to what
proteins
carbs bound to proteins covalently are called
glycoproteins
what enables cells to differentiate inbetween themselves
the diversity and location of carbohydrates on the surface
membrane proteins and lipids are synthesized in the cell where
endoplasmic reticulum
when are carbs added to the member proteins
after the er
where do the glycoproteins undergo further carb modification and lipids acquire carbs
in the golgi apparatus
what and where with what is transported after the golgi apparatus puts this stuff together
glycoproteins, glycolipids, and secretory proteins are then transported in vesicles to the plasma membrane
what process releases the secretory proteins and positions the glyco carbs and proteins outside of the membrane
exocytosis
how do hydrophilic substances avoid the hydrophobic portions of the membrane
transport proteins
channel proteins have a tunnel through the membrane that allow water to go through are called
aquaporins
without aquaporins what would happen
water would pass very slowly
carrier proteins are very what
selective
selective permeability of the membrane depends on what
the lipid bilayer and the proetins
what type of energy do molecules have
thermal energy
why do cells have thermal energy
constant motion
what is a type of thermal energy
diffusion
diffusion is
the movement of any substance so it spreads out evenly
in diffusion substances are moved how gradient
down the concentration gradient its own independent of others
what is tonicity
the ability of a surrounding solution to cause a cell to gain or lose water
what does tonicity rely on
solutes
a cell without rigid walls cannot tolerate what
excessive uptake or loss of water
what is osmoregulation
the control of solute and water balance
if an organism doesnt have a rigid cell wall and is in an extreme environment what does it need
osmoregulation mechanisms
example of osmoregulation mechanisms
plasma membranes which are less permeable to water and a vacuole which pumps water out
what is turgor pressure
pressure a plant cell wall puts back on the cell that nulls further water uptake
what is turgid cell
very firm, healthy plant cell state
what happens if a plants cell is surrounded in isotonic
it becomes flaccid
what is plasmolysis
the shriveling and plasma membrane pulling away from the wall in a plant cell
when does plasmolysis occur
when plant cell is in a hhypertonic solution
what are channel proteins that transport ions
ion channels
most ion channels are what type
gated channels
how do gated channels respond
open and close to stimulus
what are the two stimulation that open and close gated channels
electrical potential gradients and a substance adhereing to the protein
cystinuria is what
an inherited gene that has no carrier protein to transport cysteine
an inherited gene that has no carrier protein to transport cysteine called cytinuria impacts what
kidney cells and the transport of cysteine to return it to the blood