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51 Cards in this Set
- Front
- Back
HIV resistant individuals have what
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a rare form of a gene
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what does the rare form of the gene do in HIV resistant people
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it codes for an immune cell surface protein
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what is the immune cell surface protein that cods genes for hiv resisitant people
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CCR5
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what is hiv main binding site
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CD4
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what is the coreceptor required for HIV
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CCR5
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what do individuals who are hiv resisistant lack in regards to CD4 and CCR5
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they do not have a binding site for CCR5
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why is this breakthrough with HIV important
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CD4 inhibiting is dangerous. If we can inhibit CCR5, it would be a safer target and we can develop drugs that mask CCR5 and block entry.
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what is maraviroc
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a CCR5 inhibitor that has been approved for treatment of HIV
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what is crucial to the function of an organism
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cell to cell recognition
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what 2 main reasons is cell to cell recognition important
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it sorts cells into tissue and organs in embryo
the basis for rejection in immunity |
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how do cells recognize one another
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binding molecules
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what are the binding molecules on cells containing
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carbohydrates
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where are the carbohydrates that allow binding molecules to recognize other cells located
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extracellular plasma membrane
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describe membrane carbohydrates
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short branched chains of fewer than 15 units
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what type of bonding occurs in between carbohydrate molecules and lipids
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covalent
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carbohydrate molecules covalently bonded to lipids are called
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glycolipids
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most carbs are bound covalently to what
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proteins
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carbs bound to proteins covalently are called
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glycoproteins
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what enables cells to differentiate inbetween themselves
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the diversity and location of carbohydrates on the surface
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membrane proteins and lipids are synthesized in the cell where
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endoplasmic reticulum
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when are carbs added to the member proteins
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after the er
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where do the glycoproteins undergo further carb modification and lipids acquire carbs
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in the golgi apparatus
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what and where with what is transported after the golgi apparatus puts this stuff together
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glycoproteins, glycolipids, and secretory proteins are then transported in vesicles to the plasma membrane
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what process releases the secretory proteins and positions the glyco carbs and proteins outside of the membrane
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exocytosis
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how do hydrophilic substances avoid the hydrophobic portions of the membrane
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transport proteins
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channel proteins have a tunnel through the membrane that allow water to go through are called
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aquaporins
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without aquaporins what would happen
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water would pass very slowly
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carrier proteins are very what
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selective
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selective permeability of the membrane depends on what
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the lipid bilayer and the proetins
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what type of energy do molecules have
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thermal energy
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why do cells have thermal energy
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constant motion
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what is a type of thermal energy
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diffusion
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diffusion is
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the movement of any substance so it spreads out evenly
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in diffusion substances are moved how gradient
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down the concentration gradient its own independent of others
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what is tonicity
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the ability of a surrounding solution to cause a cell to gain or lose water
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what does tonicity rely on
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solutes
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a cell without rigid walls cannot tolerate what
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excessive uptake or loss of water
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what is osmoregulation
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the control of solute and water balance
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if an organism doesnt have a rigid cell wall and is in an extreme environment what does it need
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osmoregulation mechanisms
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example of osmoregulation mechanisms
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plasma membranes which are less permeable to water and a vacuole which pumps water out
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what is turgor pressure
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pressure a plant cell wall puts back on the cell that nulls further water uptake
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what is turgid cell
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very firm, healthy plant cell state
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what happens if a plants cell is surrounded in isotonic
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it becomes flaccid
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what is plasmolysis
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the shriveling and plasma membrane pulling away from the wall in a plant cell
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when does plasmolysis occur
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when plant cell is in a hhypertonic solution
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what are channel proteins that transport ions
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ion channels
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most ion channels are what type
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gated channels
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how do gated channels respond
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open and close to stimulus
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what are the two stimulation that open and close gated channels
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electrical potential gradients and a substance adhereing to the protein
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cystinuria is what
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an inherited gene that has no carrier protein to transport cysteine
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an inherited gene that has no carrier protein to transport cysteine called cytinuria impacts what
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kidney cells and the transport of cysteine to return it to the blood
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