Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
Define electrical transmission
|
Direct flow of ions from one neuron to another hence direct inflence of electric current from one to another
|
|
|
Gap junction is a form of (electrical/chemical) transmission
|
Electrical
|
|
|
How many connexin subunit makes 1 connexon hemichannel?
|
6
|
|
|
Gap junctions are modulated by 3 factor
|
pH
Neurotransmitter Ca2+ |
|
|
Gap junctions may play a role in e________ activity
|
epileptiform
|
|
|
Transmission of action potentials in gap junctions are g_______
|
graded
|
|
|
Define chemical transmiision
|
Neurotransmitter substance released from presynaptic cell, diffuses across synaptic cleft, produces effect on postsynaptic neuron
|
|
|
A central synapse is a form of (electrical/chemical) transmission
|
chemical
|
|
|
The distance between pre and post synaptic cell membranes in electrical synapse is (3.5/30-50)mm
|
3.5
|
|
|
The distance between pre and post synaptic cell membranes in chemical synapse is (3.5/30-50)mm
|
30 - 50mm
|
|
|
There is a cytoplasmic continuity between pre and post synaptic cell membrane (chemical/electrical) synapse
|
electrical
|
|
|
What are the ultrastructural components in electrical synapse?
|
gap junction channels
|
|
|
What are the ultrastructural components in chemical synapse?
|
Pre-synaptic active zones and vesicles, postsynaptic receptors
|
|
|
What is the agent of transmission in electrical synapse
|
Ionic current
|
|
|
What is the agent of transmission in chemical synapse
|
Chemical transmitter
|
|
|
What is the synaptic delay in electrical synapse?
|
Absent
|
|
|
What is the synaptic delay in chemical synapse?
|
Usually 1 - 5ms
|
|
|
(Bidirectional/Unidirection) in electrical synapse
|
Bidirectional
|
|
|
(Bidirectional/Unidirection) in chemical synapse
|
Unidirectional
|
|
|
What is the flexibility in electrical synapse
|
None
|
|
|
What is the flexibility in chemical synapse
|
Great flexibility due to transmitter and postsynaptic response
|
|
|
(amino acids/amines/peptides) neurotransmitters are synthesised in the axon terminal using specific enzymes produced in the cell body
|
amino acids and amines
|
|
|
(amino acids/amines/peptides) neurotransmitters are contained into secretory granules and are carried to the axon terminal via axoplasmic transport
|
peptides
|
|
|
What are the 4 criterias for a chemical messenger to be considered a neurotransmitter
|
must be synthesised in the neuron
must be present in the presynaptic terminal and be released in amounts sufficient to exert its supposed effect When applied exogenously it must mimic exactly the actions of the endogenous molecule must have a specific mechanism for removing it from its site of action |
|
|
What are the 2 type of synaptic vesicles
|
Small clear vesicle
Large dense core vesicle |
|
|
What is the term for a single neuron synthesising and releasing more than one transmitter substance?
|
Co-existence or co-transmission
|
|
|
(Synaptobrevin/synaptotagmin) is a vesicle bound protein which binds with SNAP-25 on the plasma membrane
|
Synaptobrevin
|
|
|
(Synaptobrevin/synaptotagmin) is a Ca2+ sensor
|
Synatotagmin
|
|
|
(EPP/MEPP) are action potential dependent
|
EPP
|
|
|
(EPP/MEPP) are spontaneous and occurs in the absense of action potentials
|
MEPP
|
|
|
(Metabotropic/Ionotropic) receptors are coupled to intracellular proteins that transduce the signal to the cell interior
|
Metabotropic
|
|
|
(Metabotropic/Ionotropic) receptors form ion channels, that depolarise or hyperpolarise the postsynaptic cell
|
Ionotropic
|
|
|
(Metabotropic/Ionotropic) receptors are slow response
|
Metabotropic
|
|
|
(Metabotropic/Ionotropic) receptors are fast response
|
Ionotropic
|
