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34 Cards in this Set

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Define electrical transmission
Direct flow of ions from one neuron to another hence direct inflence of electric current from one to another
Gap junction is a form of (electrical/chemical) transmission
Electrical
How many connexin subunit makes 1 connexon hemichannel?
6
Gap junctions are modulated by 3 factor
pH
Neurotransmitter
Ca2+
Gap junctions may play a role in e________ activity
epileptiform
Transmission of action potentials in gap junctions are g_______
graded
Define chemical transmiision
Neurotransmitter substance released from presynaptic cell, diffuses across synaptic cleft, produces effect on postsynaptic neuron
A central synapse is a form of (electrical/chemical) transmission
chemical
The distance between pre and post synaptic cell membranes in electrical synapse is (3.5/30-50)mm
3.5
The distance between pre and post synaptic cell membranes in chemical synapse is (3.5/30-50)mm
30 - 50mm
There is a cytoplasmic continuity between pre and post synaptic cell membrane (chemical/electrical) synapse
electrical
What are the ultrastructural components in electrical synapse?
gap junction channels
What are the ultrastructural components in chemical synapse?
Pre-synaptic active zones and vesicles, postsynaptic receptors
What is the agent of transmission in electrical synapse
Ionic current
What is the agent of transmission in chemical synapse
Chemical transmitter
What is the synaptic delay in electrical synapse?
Absent
What is the synaptic delay in chemical synapse?
Usually 1 - 5ms
(Bidirectional/Unidirection) in electrical synapse
Bidirectional
(Bidirectional/Unidirection) in chemical synapse
Unidirectional
What is the flexibility in electrical synapse
None
What is the flexibility in chemical synapse
Great flexibility due to transmitter and postsynaptic response
(amino acids/amines/peptides) neurotransmitters are synthesised in the axon terminal using specific enzymes produced in the cell body
amino acids and amines
(amino acids/amines/peptides) neurotransmitters are contained into secretory granules and are carried to the axon terminal via axoplasmic transport
peptides
What are the 4 criterias for a chemical messenger to be considered a neurotransmitter
must be synthesised in the neuron
must be present in the presynaptic terminal and be released in amounts sufficient to exert its supposed effect
When applied exogenously it must mimic exactly the actions of the endogenous molecule
must have a specific mechanism for removing it from its site of action
What are the 2 type of synaptic vesicles
Small clear vesicle
Large dense core vesicle
What is the term for a single neuron synthesising and releasing more than one transmitter substance?
Co-existence or co-transmission
(Synaptobrevin/synaptotagmin) is a vesicle bound protein which binds with SNAP-25 on the plasma membrane
Synaptobrevin
(Synaptobrevin/synaptotagmin) is a Ca2+ sensor
Synatotagmin
(EPP/MEPP) are action potential dependent
EPP
(EPP/MEPP) are spontaneous and occurs in the absense of action potentials
MEPP
(Metabotropic/Ionotropic) receptors are coupled to intracellular proteins that transduce the signal to the cell interior
Metabotropic
(Metabotropic/Ionotropic) receptors form ion channels, that depolarise or hyperpolarise the postsynaptic cell
Ionotropic
(Metabotropic/Ionotropic) receptors are slow response
Metabotropic
(Metabotropic/Ionotropic) receptors are fast response
Ionotropic