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20 Cards in this Set

  • Front
  • Back

Primary Lymphatic Organ

* Lymphocyte production and maturation
* Bone marrow
* thymus

bone marrow

produce B and T cells


B cells mature in bone marrow

Thymus

T cells mature in thymus

Secondary Lymphatic Organ

* Where mature lymphocytes go to look for their targets
* Lymph nodes
* spleen
* mucosa- associated tissue

Lymph nodes

* Where APC's accumulate after finding infection in the body tissue

Spleed

* Where APC's go after finding infection in blood

Mucosa-associated lymphoid tissue

* Filled with immune cells

Nonspecific (Innate) Resistance to Disease

* Fast response
* Skin - first line of defense

Skin

* Oil and sweat with lysozymes
* Antimicrobial peptides
* Beneficial bacteria and fungi

Phagocytes

* Kill pathogens by phagocytosis
* Kill and digect microbe

Inflammation

* Chemical alarm signals may be release
* Causes dilation
* Increases permeability of capillaries
* Cell recruitment
* Cytokine release

Fever

* Promotes activity of phagocytes
* Reduced blood iron levels
* Storage of iron decreases bacteria growth

Specific (Acquired) Immunity

* Specific weapons for specific response
* T cells and B cells

Diversity
* Specify
* Memory

Antigen

* Molecule that incites a specific immune response

Antibodies

* Proteins that bind to antigens in order to cause a response
* Heavy and light chains

Interlock to form a YVariable region is for antibody specify
* 5 classesIgM
* IgD
* IgG
* IgA
* IgE

Lymphocytes

Cells responsible for adaptive immunity


B cells


T cells

B cells

* Humoral immunity
* Produce antibodies
* B cells activated by helper T cell

T cells

Cell mediated immunity

Cellular (cell-mediated) immunity

* Class 1

In every nucleated cell
* Activate cytotoxic T cellsInvolved in cell mediated immunity
* Class 2Activate helper T cellsCytokines to signal other cells
* Determine cellular or humoral response

Allergies

* Immune system response too strongly to pathogens that only require a minor response
* Immediate hypersensitivity
* ACP activated Helper T cells, activated B cells, sensitize innate immune cells, causes inflammation when encounter allergen
* Systemic anaphylaxis and anaphylactic shock