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68 Cards in this Set
- Front
- Back
the field of genetics that involves the microscopic examination of chromosomes |
cytogenetics |
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reveals the number, size, and form of chromosomes found within an actively dividing cell |
karyotype |
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the two copies of chromosomes that have already replicated |
sister chromatids |
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the chromosomes tat are not sex chromosomes |
autosomes |
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humans ave ---- different types of autosomes |
22 |
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when an organism carry two sets of chromosomes, that organism is said to be ___ |
diploid |
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human cells that are haploid |
sperm and egg cells (1n) |
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the members of a pair of chromosomes from a diploid |
homologs |
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the sperm and egg cells are referred to as ______ |
gametes |
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the phases of the cell cylce |
G1 (first gap) S (synthesis of DNA) G2 (second gap) M phase (mitosis and cytokinesis) |
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collectively known as interphase |
G1 S G2 |
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during ______ the cell grows and copies its chromosomes in preparation for cell division |
interphase |
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is a nondividing phase |
G0 |
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during this phase, each chromosome is replicated to form a pair of sister chromatids |
S phase |
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during this phase, a cell synthesizes the proteins necessary for chromosome sorting and cell division |
G2 phase |
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the division of the cytoplasm to produce two distinct daughter cells |
cytokinesis |
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the division of once cell nucleus into two nuclei |
mitosis |
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proteins responsible for advancing a cell through the phases of the cell cycle |
cyclins cyclin-dependent kinases (cdks) |
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when is G1 cylcin degraded? |
after the cell passes into S phase |
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accumulates late in G2; binds to a cdk to form an activated mitotic cyclin/cdk complex |
mitotic cyclin |
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this complex phosphorylates proteins that are needed to advance the cell into M phase |
mitotic cyclin/cdk complex |
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these proteins act as sensors to determine if a cell is in the proper condition to divide |
checkpoints |
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aka G1 checkpoint -- can sense if the DNA has incurred damage |
restriction point |
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monitors the levels of proteins that are needed to progress through M phase |
G2 checkpoint |
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senses the integrity of the spindle apparatus |
metaphase checkpoint |
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a process in which genetically identical offspring are produced from a single parent |
asexual reproduction |
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a structure necessary for sorting each chromosome |
kinetochore |
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responsible for organizing and sorting the chromosomes during cell division |
mitotic spindle |
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aka MTOC - microtubule organizing centers |
centrosomes |
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3 types of spindle microtubules |
astral - positions the spindle apparatus polar - separates the two poles kinetochore -- sorts each chromosome |
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observed mitosis in 1871 |
Walther Flemming |
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in this phase the mitotic spindle is fully formed; centrosomes move apart and demarcate the two poles |
prometaphase |
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the pairs of sister chromatids are aligned in a single row during this phase |
metaphase |
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during this phase, the chromosomes have reached their respective poles and decondense |
telophase |
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the connections between the pairs of sister chroatids are broken |
anaphase |
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constriction of cells like a drawstring to separate the cells |
cleavage furrow |
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forms a cell wall between the two daughter cells |
cell plate |
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occurs when two nuclei are segregated into separate daughter cells |
cytokinesis |
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what are the results of mitosis and cytokinesis? |
production of two daughter cells with the same number of chromosomes as the mother cell ensures genetic consistency from once cell to the next |
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approximately ___ proteins are involved with cytokinesis |
20 |
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the 20 conserved proteins perform 4 functions : |
contractile ring signal transduction central spindle cell separation via membrane insertion |
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when two haploid gametes unite, it forms a _____ |
zygote |
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the process by which haploid cells are produced from a cell that was originally diploid |
meiosis |
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in meiosis, sister chromatids associate with each other forming a____ |
bivalent (aka tetrad) |
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the process of forming a bivalent |
synapsis |
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involves a physical exchange between chromosome segments of the bivalent |
crossing over |
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the ____ becomes visible as chromosome arms separate during late prophase |
chiasma |
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2 key events that occur at the beginning of meiosis that do not occur in mitosis |
bivalent formation crossing over of chromosome segments |
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the sequence of events that produces another generation of organisms |
life cycle |
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animals are ______ |
diploid-dominant species |
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most fungi and some protists are _____ |
haploid-dominant species |
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plants and algae are -______ |
alternation of generations |
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the species of plants and algae alternate between diploid multicellular organisms called _______, and haploid multicellular organisms called _________ |
sporophytes gametophytes |
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animals produce gametes by ______ |
meiosis |
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plants and fungi produce reproductive cells by ______ |
mitosis |
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chromosomal mutations are categorized into four: |
deletions duplications inversions translocations |
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organisms that have chromosomes that occur in ore or more complete sets |
euploid |
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organisms with three or more sets of chromosomes |
polyploid |
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refers to an alteration in the number of particular chromosomes, so the total number of chromosomes is not an exact multiple or set |
aneuploidy |
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refers to an event in which the chromosomes do not separate properly during cell division |
nondisjunction |
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in which phase of the cell cycle are chromosomes replicated? |
S phase |
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if 2 chromosomes are homologous, they: |
look similar under a microscope have very similar DNA sequences carry the same types of genes may carry different versions of the same gene |
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checkpoints during the cell cycle are important because they: |
ensure the integrity of the cell's DNA |
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what are reasons for mitotic cell division |
asexual reproduction multicellularity |
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the nuclear envelope breaks down in what phase of mitosis? |
prophase |
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what phase is the cell in? 2N (n=7) the cell has 7 replicated chromosomes sister chromatids are aligned at the metaphase plate of the cell |
metaphase of meiosis II |
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a replicated chromosome is composed of |
two sister chromatids held together at the centromere |
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aneuploidy may be the result of: |
nondisjunction during meiosis |