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15 Cards in this Set
- Front
- Back
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EPSP
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Excitatory post synaptic potential
Influx of Na+, reduces voltage gradient Depolarize Increase likelihood of AP |
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IPSP
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Inhibitory post synaptic potential
Efflux of K+ (or influx of Cl-) increases voltage gradient Hyperpolerize Decreases likelihood of AP |
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Spontaneous firing
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periodic APs, Postsynaptic potentials alter the firing sequence
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Voltage-gated calcium gates
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When the AP reaches the end of the axon, the depolarization opens these gates and calcium pushes out neurotransmitters
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Exocytosis
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Release of neurotransmitter in bursts from the presynaptic neuron into the synaptic cleft.
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Glutamate
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Major excitatory NT
binding opens Na+ channels |
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GABA
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Major inhibitory NT
Binding opens chloride channels |
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Acetylcholine
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Found at neuromuscular junction in brain
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Ionotropic Effects
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NT attaches to receptor and channel opens
Fast acting |
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Metabotropic effects
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Slower, longer lasting effects
Can influence entire cell G-Protein coupling |
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Reuptake
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When the presynaptic neuron takes up most of the NT and reuses them.
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Antagonist
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Drug inhibits NT activity
Block post synaptic receptors NT leak out of vesicles Blocks release of NT from axon |
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Agonist
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Drug that mimics or enhances NT.
Blocks reuptake Boosts postsynaptic activity |
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Spatial Summation
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How many senders there are to one neuron
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Temporal Summation
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How many releases one neuron lets out.
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