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20 Cards in this Set
- Front
- Back
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Carcinoma
cell of origin? IHC stain? |
-epithelial
-keratin, cytokeratin, epithelial membrane antigen |
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Sarcoma
cell of origin? IHC stain? |
-Mesenchymal
-Vimentin |
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Rhabdomyoma, rhabdomyosarcoma
cell of origin? IHC stain? |
-muscle (skeletal)
-Desmin, muscle specific actin (MSA) |
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Leukemia, Lymphoma
cell of origin? IHC stain? |
-Leukocyte
-Leukocyte common antigen (LCA) |
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Neuroblastoma, carcinoid tumor, small cell carcinoma
cell of origin? IHC stain? |
-Neuro-endocrine
-Neuron specific enolase (NSE), chromogranin, bombesin, synaptophysin, S-100 |
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Melanoma
cell of origin? IHC stain? |
-melanocyte
-S-100, melanin, HMB-45 |
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Glioma
cell of origin? IHC stain? |
-Glial cells
-Glial fibrillary acidic protein (GFAP) |
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Thyroid cancer
cell of origin? IHC stain? |
-thyroid follicle
-thyroglobulin |
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Acute lymphoblastic leukemia
cell of origin? IHC stain? |
-Lymphoblast, B cell/T cell
-B cell-CD10 (CALLA) |
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Seminoma
cell of origin? IHC stain? |
-Germ cell of tumor of testes
-placental alkaline phosphatase (PLAP), B-hCG |
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Yolk sac tumor
cell of origin? IHC stain? |
-Germ cell tumor of testes/ovaries
-Alpha-feto protein (AFP) |
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Vascular neoplasms
cell of origin? IHC stain? |
-Blood vessels
-vWF, CD31 |
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Squamous cell carcinoma
cell of origin? structure on EM? |
-epithelial
-tonofilament |
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Angiosarcoma
cell of origin? structure on EM? |
-Endothelial cell origin (mesenchymal)
-Weibel palade bodies |
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Small cell carcinoma (in the lung)
cell of origin? Structure on EM? |
-neuro endocrine
-neuro-secretory granules |
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Malignant melanoma
cell of origin? structure on EM? |
-melanocyte
-melanosome |
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Histiocytosis X
cell of origin? structure on EM? |
-Histiocytes
-Birbeck granules (tennis racket appearance) |
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What is desmoplasia?
(ex?) |
-hyperplasia of activated fibroblasts- abundant collagenous stroma
(Ex: breast cancer, stony hard or scirrhous) |
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What are some angiogenic factors tumors induce?
-therapy implication? |
-VEGF, bFGF, HIF (hypoxia inducible factor)
-loss of angiogenesis inhibitors (Thrombospondin-1) -Bevacizumab, or monoclonal AB against VEGF with chemo |
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What indicators are used to show tumor proliferation?
(2 types of stains) |
Ki-67
PCNA= proliferating cell nuclear antigen |
