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26 Cards in this Set
- Front
- Back
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embryonic stem cells |
pluripotent cell lines derived from mammalian blastocysts
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homologous recombination
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the reciprocal exchange of sequences between two homologous DNA strands. It is widely used to introduce targeted and specific modifications in prokaryotic and eukaryotic genomes.
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aneuplody
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any deviation from the normal haploid number of chromosomes
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karyotype
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a standard arrangement of the chromosome comlement; a normal human female karyotype would have each of the 22 pairs of autosomes arranged in numerical order together with the two X chromosomes
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pluripotent
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the capacity to give rise to cells representing all germ layers
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cell fate
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future possible course of differentiation of a given cell
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cell lineage
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set of courses of differentiation that leads to a give cell type
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differentiation
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changes in biological, physical, and / or chemical cell properties associated with the development of final cell types of an organism
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proliferation
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cell division without a change in cell properties
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pluripotent
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capability of a cell to develop into many, but not all, the cell types of an organism
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totipotency
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capability of a cell to develop into all cell types of an organism
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gynogenesis
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manipulation of ploidy by suppression of the polar body in an egg lacking paternal genetic contribution
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hemangioblast
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the postulated bipotential cell that would give rise to hematopoietic and endothelial cell lineages in vertebrates
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hematopoiesis
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the formation and development of blood cells
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bioethics
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the study of the norms of conduct that should govern research and clinical applications of biomedical technologies
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stem cells
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self-renewing (immortalized), unspecialized cells that give rise to multiple types of all specialized cells
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therapeutic cloning
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the deliberate creation of a human organism by nuclear transfer technology in order to produce an embryo that can be used to create a stem cell line that will not provoke an immune response and rejection
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moral realism
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theory of knowledge that affirms the possibility of at least partial correspondence between what is in reality and what is in the mind
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ontological
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having to do with the structure of being
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primitive streak
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the initial band of cells from whcih the individuated embryo begins to develop; it is present at approximately 14 days after fertilization
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cGMPs
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(current Good Manufacturing Practices) the most up to date scientifically sound methods, practices or principles that are implemented and documented during product development and production to ensure consistent manufacture of safe, pure, and potent products
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identity
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the use of
physical or chemical characteristics of the product, inspection by macroscopic or microscopic methods, or specific culture tests of ''in vivo'' or ''in vitro'' tests to sufficiently identify a product and distinguish it from any other product being processed in the same laboratory |
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manufacture
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all steps involved in propagation or processing and preparation of therapeutic products including, but not limited to filling, testing, labeling, packaging, and storage as performed by the manufacturer [21 CFR 600.3(t)]
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potency
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the specific ability or capacity of a therapeutic product to elicit an expected result, as indicated by appropriate laboratory tests or by adequately controlled clinical data obtained through the administration of the product in the manner intended [21 CFR 600.3(s)]
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purity
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relative freedom from extraneous matter in the finished product introduced during the manufacturing process, whether or not harmful to the recipient or deleterious to the product [21 CFR 600.3(r)]
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stability
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ability of a product to retain its sterility, identity, purity, and potency over time when stored and shipped in designated packaging and under specific conditions
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