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19 Cards in this Set
- Front
- Back
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Depolarized .... and inactivation of V-gated Na+ chennels makes action potentials unidirectional
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What happen ?
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Depolazation of the axon terminal triggers
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neurotransmitter release
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Neurotransmitter and receptors for neurotransmitters diffuse across the synatic cleft
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the cleft is extremely small
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Neuritrasmitters are small chemical compounds
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Serotonin (Happiness), Acetylcholine (Muscle contraction), Dopamine (reward)
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Axon terminals contain voltage-gated Ca2+ channels
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Calcium ion influx triggers exocytosis of neurotransmitters.
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Binding of neurotransmitter causes depolarization of
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the target cell. Binding of neurotransmitter causes depolarization of the target cell.
Neuroreceptors 1. Ligand-gated 2. GPCR |
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THe acetylcholine receptor is a ligand-gated ion channel
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sodium, calcium or any ions can flow through.
It actually facillitate the influx of sodium into the cells. |
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A package of neurotransmitter and
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get these vesicle ready !
Neurotransmitters are packaged into synaptic vesicles by H+ gradients |
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Neurotransmitters are packaged into synaptic vesicles by
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H+ gradients
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Synaptic vesicles are docked at the plasma membrane
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by SNARE complexes
BOtulinum toxin ( snare complex, undocking and complete ...) |
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BOTOX undocks synaptic vesicles
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and prevents acetylcholine realeases. The SNARE is degraded and fully block synaptic transcription.
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people with botox can't smile
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because their facial is paralyze. Botox treatment will last 3-4 months
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How do you trigger exocytosis
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Ca 2+ influx causes membrane fusion and neurotransmitter release.
Synaptotagmin is the Ca 2+ sensor. |
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Synatic vesicle fusion may occur by a kiss and run mechanism
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partially fused and never a flattened out : transient release
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Reuptake of neurotransmitters occurs by Na symporters
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Reuptake of neurotransmitters occurs by Na+ synporters.
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Recycling of the synaptic vesicle requires the GTPase Dynamin
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Dynamin form helixes and twisted the ( kind da like a boa)
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Shibire mutation
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numbness mutation. fly in japanese
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Only 10% of docked vesicles are used per firing
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why synaptic vessicls ae so full of vesicles
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Package with V class H punp and move to the surface and docked by snare
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calcium influx => fusion of synaptic vesicle. Neurotransmitter is symport with Na and the vesicles is catherin and dynamin proteins
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