Biochemistry - Tca Cycle

Front 1

3 names for TCA cycle

Back 1

Krebs
Tri-carboxylic Acid (TCA) cycle
Citric Acid Cycle

Front 2

Amphibolic

Back 2

Both breaks down and builds up.
Contribues to catabolic and anabolic metabolism

Front 3

Reactions of 8 Steps????

Back 3

1. condensation
2. Isomerisation
3. Dehydrogenase (Redox)
4. Dehydrogenase (Redox)
5. GTP generated - hydrolysis
6. Dehydrogenase (Redox)
7. Hydration
8. Dehydrogenase (redox)

Front 4

Molecule that feeds into TCA cycle

Back 4

Acetyl CoA

Front 5

Order of molecules?

Back 5

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Acetyl CoA
Citrate
Isocitrate
(Alpha) Ketoglutarate
Succinyl CoA
Succinate
Fumarate
Malate
Oxaloacetate (OAA)

Front 6

8 enzymes (In order from Acetyl CoA)

Back 6

1. Citrate synthase
2. Aconitase
3. Isocitrate Dehydrogenase
4. Alpha Ketoglutarate Dehydrogenase
5. Succinyl CoA Synthase
6. Succinate Dehydrogenase
7. Fumarase
8. Malate Dehydrogenase

Front 7

For each molecule of NADH from TCA cycle ____ ATP molecules are produced

Back 7

3

Front 8

For each molecule of FADH2 from the TCA cycle _____ molecules of ATP are produced

Back 8

2

Front 9

For each turn of the cycle _____ ATP molecules are made

Back 9

12

Front 10

Can be used in pyruvate and glucose (from TCA cycle)

Back 10

Malate

Front 11

Can be used in Asparate, purines, pyrimidines, amino acids, and glucose (from TCA)

Back 11

OAA (Oxyloacetate)

Front 12

Can be used in fatty acids, cholesterol, and steroids (from TCA)

Back 12

Citrate

Front 13

Can be used in Glutamine, Glutamate, Purines, and other amino acids (From TCA)

Back 13

Alpha Ketoglutarate

Front 14

Can be used in Porphyrins (Heme and Chlorophyll) (From TCA)

Back 14

Succinyl CoA

Front 15

Anaplerotic

Back 15

A metabolic reaction that replenishes intermediates of TCA cycle (Fills up)

Front 16

3 main regulation points in TCA pathway (and most important?)

Back 16

1. citrate synthase is inhibited by citrate and ATP and activated by Acetyl CoA and Oxaloacetate.
2. Isocitrate dehydrogenase is inhibited by NADH and ATP and activated by ADP.
3. Alpha ketoglutarate dehydrogenase is inhibited by NADH and Succinyl CoA and activated by Calcium Ions.

Rate of formation of Alpha Ketogluterate is important in overal cycle control