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14 Cards in this Set
- Front
- Back
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What is the abbreviation for Beta Oxidation?? And what does it stand for??
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DHDT
Dehydrogenation Hydration Dehydrogenation Thiolytic Cleavage |
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Where are fatty acyl-CoAs formed
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On the outer mitochondrial membrane
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What is the purpose of Carnitine?
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To transport acyl-CoA's into the mitochondria for oxidation
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Once inside the mitochondria where does oxidation of the acyl-CoA's happen?
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the Beta-Carbon
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What is the carrier called that transfers th efatty acyl from the cytosol to the intermembrane space?
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Carnitine acyltransferase I
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How is the process completed to get the fatty acyl-CoA into the matrix?
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Once the fatty acyl-CoA is transported to the intermembrane space it yeilds Fatty acyl-carnitine and carnitine acyltransferase II exchanges fatty acyl carnitin for free carnitine and produces fatty acyl-CoA
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What happens in the first step in Beta Oxidation?
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Initial Dehydrogenation. Catalyzed by fatty acyl-CoA dehydrogenase
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What happens in reaction 4 of Beta Oxidation
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The Thiolytic Cleavage. Involves the attack of the nucleophilic thiol sulfur of coenzyme A to cleave the alpha and beta bond and release acetyl Co-A.
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What are the intermediates in the Pyruvate Dehydrogenase Complex?
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TPP- Thiamine Pyrophosphate
Lip-Lipoic Acid FAD NAD CoA-Coenzyme A |
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What is the TCA cycle acronym and what does it stand for?
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Our City Above Is Kept Safe Sound From Malice
Oxaloacetate Citrate cis-Aconitate Isocitrate Succinate Formate Malate |
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What is formed from the TCA cycle?
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Oxaloacetate
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Why is the pyrovate dehydrogenase complex important
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it is needed ton convert pyrovate to Acetyl-CoA
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Overall glycolysis yields what?
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glucose-->>2 pyruvates
2ADP-->>2ATP 2NAD-->>NADH |
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What happens in reactions 2 and 3 of Beta Oxidation?
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Hydration and Dehdrogenation. Hydration of the double bond formed in step 1 and dehydrogenation of the hydroxyl group. Catalyzed by enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase.
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