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9 Cards in this Set

  • Front
  • Back
how do you get from gln to glu
glutaminase
how do you get from asn to asp
asparaginase
what is the main methyl donor
SAM
homocystein + adenosine --> THF and methionine. What is required here?
B12
in order to transfer the methylene carbon from 5,10mTHF to dUMP, simultaneous internal oxidation must occur with ____ production of ___
THF DHF
________ ______ inhibitors are used to inhibit proliferation by blocking regeneration of 5,10me THF which blocks dTMP and therefore DTTP and therefore DNA synthesis in rapidly dividng cells
dihydrofolate reductase
why do megaloblasts form
inhibition of nromal DNA synthesis and cell division
lack of nucleotide precursors
lack of B6 might cause buildup of ______
homocysteine
What wasn’t fixed by excess folate supplementation
if patient has a B12 deficiency?
MethylmalonylCoA accumulation and
methylmalonate aciduria in blood leading to
life threatening neurological problems.