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9 Cards in this Set
- Front
- Back
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how do you get from gln to glu
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glutaminase
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how do you get from asn to asp
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asparaginase
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what is the main methyl donor
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SAM
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homocystein + adenosine --> THF and methionine. What is required here?
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B12
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in order to transfer the methylene carbon from 5,10mTHF to dUMP, simultaneous internal oxidation must occur with ____ production of ___
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THF DHF
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________ ______ inhibitors are used to inhibit proliferation by blocking regeneration of 5,10me THF which blocks dTMP and therefore DTTP and therefore DNA synthesis in rapidly dividng cells
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dihydrofolate reductase
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why do megaloblasts form
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inhibition of nromal DNA synthesis and cell division
lack of nucleotide precursors |
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lack of B6 might cause buildup of ______
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homocysteine
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What wasn’t fixed by excess folate supplementation
if patient has a B12 deficiency? |
MethylmalonylCoA accumulation and
methylmalonate aciduria in blood leading to life threatening neurological problems. |
