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20 Cards in this Set
- Front
- Back
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the slowing of ETC will in turn lead to slowing ofr the ____ cycle and _____ _____ and also ________ of FACoAs
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slowing of the TCA cycle
pyruvate DH beta oxidation |
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what causes fatifue in a 100 m sprint? 200m? 1500 run? marathon?
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depletion of ATP and creatineP
lactate High pi low pH glycogen depletion |
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______ regulates hte mobiolization of fuels during exercise
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adrenaline
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what enzyme ydrolyzes stored body fat
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hormone sensitive lipase
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ca2+ released from the sarcoplasmic reticulum during the muscle contraction has a number of ikey regulatory effects in addition to activation of the _______ ______
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myosin ATPase
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AMPkinase activates
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glycogen synthase kinase which phosphorylates and inhibits glycogen synthase
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Ca2+ and CaCM directly activate
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phosphorylase kinase which phosphorylates glycogen phosphorylase
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5'AMP directly activates
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glycogen phosphorylase
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a key event promoting glucose uptake and utilization by contracting muscle is translocation of ______
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GLUT4
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Does AMP activate or inhitit ACC? MDC?
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inhibits ACC which leads to malonylcoA and inhibition of FACoa
activates MDC which keeps acetylcoa which allows for fatty acid activation |
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T or F. exercise increases GLUT4, hexokinase, and TCA cycle and beta oxidation enzymes and glycogen synthase
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true :)
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____ ______ _____ promote synthesis of enzymes required for fat catabolism
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PPAR transcription factors
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PGC1alph is in turn a global regulator promoting txn events leading to glucose ____ and glycogen ____ and enhanced ________
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glucose uptake
glycogen storage enhanced fatty acid oxidation by muscle |
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________ are a sensitive indicator of cellular energy status
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cytoplasmic 5'AMP
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are muscle creatine phosphate and glycogen used during aerobic or anaerobic phase of exercise
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anearobic
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what is the primary fuel of initial phase of aerobic contraction? What are the two fuels of prolonged aerobic exercise
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muscle glycogen
blood glucose fatty acids |
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what are two ways to arrive at AcetycoA in muscle
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fatty acid coa
acac |
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where are KB's made
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ONLY in the liver mitochondria!
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can C's of FA be used for GNG?
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no because they are turned into CO2s in the TCA
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T or F. muscle makes FA be de novo synthesis
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false
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