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9 Cards in this Set

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Is fatty acid synthesis the exact opposite of B-oxidation?
No!
Where does fatty acid synthesis occur?

Where does B-oxidation occur?
The cytosol


In the mitochondrial matrix
Acetyl CoA transport
From the mitochondrial matirx to the cyosol using malate/citrate/pyruvate shuttle
1. Acetyl CoA-CE + malonyl-ACP-->B-ketoacyl
B-ketoacyl synthase
-CO2
2. B-ketoacyl-->B-hydroxyacyl
(ketone-->alcohol)
NADP
B-ketoacyl reductase
3. B-hydroxyacyl-->enoyl reductase
(alkane/alcohol-->alkene)
Dehydration
B-hydroxyacyl dehydratase
4. Enoyl reductase -->acyl
(alkene-->alkane)
enoyl reductase
Overall rxns for FA synthesis
1. Condensation
2. Reduction
3. Dehydration
4. Reduction
FA synthesis regulation
Insulin +
Leptin +
glucagon -