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29 Cards in this Set

  • Front
  • Back
The matured N-and O-linked sugar moieties of glycoproteins are
pre-determined by the complexity of their pre-assembled core
oligosaccharides.
False
All glycoproteins are first synthesized by free ribosomes.
True
A cell controls the quality of ER-made proteins by targeting the
mis-folded proteins to lysosome for degradation.
False
Cleavage of signal peptide sequence is an essential step for protein
synthesis to resume in ER.
False
The low pH of late endosome facilitates the dissociation of ligand receptor
complex during receptor mediated sorting process.
True
The N-linked core oligosaccharide is built up on the phosphate group of
dolichol phosphate by the successive addition of monosaccharide
(monomeric sugar) units.
True
In receptor mediated endocytosis, invagination of the plasma
membrane precedes formation of a clathrin lattice around the cytosolic
side of plasma membrane.
False
Tunicamycin blocks addition of UDP-GlcNAc to dolichol phosphate
carrier.
True
Proteins that contain internal sorting sequences retain the signals as a
part of their final protein conformation.
True
Operon is a universal gene unit.
False
The function of N-terminal signal peptide in the preproinsulin is to
direct it to the ER, from which it enters the Golgi complex and is
packaged into a secretory vesicle for transport into extracellular
compartment.
True
Mannose-6-phosphate is a key signal for directing proteins to lysosome
for degradation
False
All RNA polymerases can bind promoter by itself.
False
Eukaryotic RNA polymerase II can not bind promoter by itself.
True
Prokaryotic RNA polymerase can not bind promoter by itself.
False
Transcription in trp operon is terminated when initiation of the
translation of the leader peptide (region 1) is blocked.
False
CAP binds DNA.
False
An direct physical interaction between CAP-cAMP and i repressor
protein determines the final affinity of RNA polymerase binding to lac
promoter.
False
In ubiquitin-dependent 26S proteasome degradation pathway, the
substrate specificity of ubiquitination is determined by E2 enzyme.
False
Translocon has three sorting signal sequences.
True
The lac operon is induced whenever lactose is present.
False
The elevated cAMP level that exists when glucose is high causes CAP to
bind the lac operon and initiate transcription.
False
Attenuation in the trp operon of E. Coli is a mechanism for inhibiting
translation of existing (complete) trp mRNAs.
False
IRE-BP acts as an inhibitor for ferritin protein synthesis when
intracellular iron level is low.
True
KDEL sequence is found in flipase, translocon, and mannose-6-
phosphate receptor.
False
The bacteria culture that contains DNA fragments from a eukaryotic
organism, which has been digested with a restriction enzyme and cloned
into a lambda vector is known as cDNA library.
False
The Southern technique involves the detection of DNA fragments on
membrane using a radioactive RNA probe.
True
One of the most significant discoveries that allows the development of
recombinant DNA technology is the discovery of antibiotics used for
selecting transformed bacteria.
False
RFLP is a technique that is used to analyze alterations at a specific
genetic locus by restriction enzyme digestion, gel electrophoresis, and
Southern blotting.
True