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8 Cards in this Set
- Front
- Back
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Novobiocin
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replication/transcription inhibitor
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Flouroquinolones
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synthetic antibiotics
inhibitors of replication/transcription levofloxacin ciprofloxacin prevent reversible ligation step after the cuts in DNA |
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Ciprofloxacin
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FDA approved for Bacillus anthracis (anthrax infection)
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Gyrase
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topoisomerase type II, is the target enzyme for fluoroquinolones
a heterotetramer (GyrA2 GyrB2) |
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Topotecan
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FDA approved for ovarian cancer and small cell lung cancer
stabilizes Topo I-DNA complex and prevents the religation step (inhibition of replication) |
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Telomerase
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synthesizes telomeric repeats at the ends of DNA
a ribonucleoprotein |
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GRN163L
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oligonucleotide
13-mer complementary to template of telomerase:competetive inhibitor binding to active site of the enzyme blocks replicative potential of cancer cells |
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RHPS4
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G-quadruplex ligand
pentacyclic acridinium methosulfate; stabilizes G-quadruplex, prevents attachment of telomerase and promotes dissociation of capping protein blocks the replicative potential of cancer cells |
