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5 Cards in this Set
- Front
- Back
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phosphodiester bonds
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link nucleotides 5'C at one end to 3'OH at other end
driven by release of pyrophosphate |
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properties of nucleic acid chains
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polarity, sugar-phosphate backbone (hydrophilic), bases
phosphate group is a strong acid w/ negative charge |
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A DNA
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right handed, dehydrated
axis shifted, bp not perpendicular, major groove deep, minor shallow |
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B DNA
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right handed, fully hydrated, edges of bases are wider in major groove than minor due to asymmetrical attachment of the bp to the sugarphosphate backbone
axis runs thru center same depth 23A diameter, 3.4A btwn base ~10 bases/turn: 34A |
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Z DNA
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higher energy, left handed, helix stabilized by high salt, DNA binding proteins, methylation of C residues
more open form-may be imp for gene reg/recomb |
