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5 Cards in this Set

  • Front
  • Back
phosphodiester bonds
link nucleotides 5'C at one end to 3'OH at other end
driven by release of pyrophosphate
properties of nucleic acid chains
polarity, sugar-phosphate backbone (hydrophilic), bases

phosphate group is a strong acid w/ negative charge
A DNA
right handed, dehydrated
axis shifted, bp not perpendicular, major groove deep, minor shallow
B DNA
right handed, fully hydrated, edges of bases are wider in major groove than minor due to asymmetrical attachment of the bp to the sugarphosphate backbone
axis runs thru center
same depth
23A diameter, 3.4A btwn base
~10 bases/turn: 34A
Z DNA
higher energy, left handed, helix stabilized by high salt, DNA binding proteins, methylation of C residues
more open form-may be imp for gene reg/recomb