Biochem Unit 4 L47-L48

Front 1

Pasteur Effect

Back 1

Presence of O2 slows glucose utilization

Front 2

Adenylate Kinase

Back 2

2 ADP -> AMP + ATP
inter-membrane space protein

Front 3

Cyanide Poisoning

Back 3

Inhibits the transfer of electrons to O2 to form water thus inactivating cellular respiration

Front 4

Rotenone

Back 4

Direct Inhibitor, (insecticide, fish poison) inhibits complex I

Front 5

Amytal (Barbituates)

Back 5

Direct Inhibitor, Inhibit Complex I

Front 6

Malonate

Back 6

Direct Inhibitor, Competitive inhibitor of succinate (complex II)

Front 7

Antimycin

Back 7

Direct Inhibitor, (bacterial product) inhibits Complex III

Front 8

HCN

Back 8

Direct Inhibitor, Blocks complex IV (cytochrome oxidase)

Front 9

Atractyloside

Back 9

Indirect Inhibitor, Blocks Adenine Nucleotide Translocase (ANT)

Front 10

Oligomycin

Back 10

Indirect Inhibitor, Blocks Fo proton channel: stops proton movement through ATP Synthase

Front 11

Thermogenin

Back 11

UPC1, allows protons thru inner membrane instead of thru ATP synthase

Front 12

Dinitrophenol

Back 12

aspirin, pentachlorophenol (wood preservative), facilitate proton transport across the inner memebrane

Front 13

Valinomycin

Back 13

Bacterial ionophores, forms lipid soluble cage around K+ promoting transmembrane K+ diffusion

Front 14

Gramicidin

Back 14

Bacterial Ionophores, forms transmembrane pore that allows cations but not anions to traverse membranes

Front 15

MERRF

Back 15

Myoclonic Epilepsy with Ragged Red Fibers, Abnormal eye movements, loss of hearing, atazia, lactic acidosis, ragged red muscle fibers, progressive dementia

Front 16

MELAS

Back 16

Mitochondrial Encephalopathy with Lactic Acidosis and Stroke, Stroke-like episodes, abnormal motor and cognitive development, lactic acidosis, cardiomyopathy, deafness, dementia, and renal disease

Front 17

Leber's Hereditary Optic Neuropathy (LHON)

Back 17

Antibodies to defective Complex I ptoteins from mito DNA. Leads to blindness in young men, tremors and ataxia