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33 Cards in this Set

  • Front
  • Back
Allosteric proteins
contain distinct regulatory sites and have multiple functioning sites and display cooperativity.
Examples of covalent modification include
phosphorylation. acetylation. ubiquination.
The most common strategy(ies) for enzymatic regulation are:
multiple enzyme forms, allosteric control, reversible covalent modification, and proteolytic activation
An allosteric interaction between a ligand and a protein is one in which:
the binding of a molecule to a binding site affects the binding properties of another site on the protein.
In hemoglobin, the transition from T state to R state (low to high affinity) is triggered by:
oxygen binding.
The fundamental cause of sickle-cell disease is a change in the structure of:
A small molecule that decreases the activity of an enzyme by binding to a site other than the catalytic site is termed a(n):
allosteric inhibitor.
Allosteric enzymes:
usually have more than one polypeptide chain.
How do a nucleotide and a nucleoside differ?
A nucleotide is a nucleoside with a phosphate ester linked at the sugar 5' residue.
In the trinucleotide pApCpG, where is the free OH group?
at the 3' end
The feature(s) of DNA deduced by Watson and Crick included
two antiparallel polynucleotide chains coiled in a helix around a common axis. the pyrimidine and purine bases lie on the inside of the helix. the bases are nearly perpendicular to the axis.
A major component of RNA but not of DNA is:
The difference between a ribonucleotide and a deoxyribonucleotide is:
deoxy- has an –H instead of an –OH at C-2.
The phosphodiester bonds that link adjacent nucleotides in both RNA and DNA:
join the 3' hydroxyl of one nucleotide to the 5' hydroxyl of the next.
By definition, the 5' end of a DNA or RNA strand:
has no nucleotide attached to the 5' hydroxyl.
The DNA oligonucleotide abbreviated pATCGAC:
has 6 phosphate groups.
In a double-stranded nucleic acid, cytosine typically base-pairs with:
For the oligoribonucleotide pACGUAC:
the nucleotide at the 5' end has a phosphate on its 5' hydroxyl.
The Watson-Crick base pairing scheme for an A–T base pair includes:
a hydrogen bond between a keto oxygen and an extracyclic amino group.
a hydrogen bond between two ring nitrogen atoms.
In the Watson-Crick structure of DNA, the:
the two strands are antiparallel.
In the Watson-Crick model of DNA structure:
the distance between two adjacent bases in one strand is about 3.4 Å.
In the Watson-Crick model of DNA structure (now called B-form DNA):
the bases occupy the interior of the helix.
In double-stranded DNA:
the two strands have complementary sequences.
Adenine, Purine
What is the name of this nucleotide
Guanine, Purine
What is the name of this nucleotide?
Cytosine, Pyrimidine
What is the name of this nucleotide
Uracil, Pyrimidine
What is the name of this nucleotide
Thymine, Pyrimidine
What is the name of this nucleotide?
A form, B form, Z form
name the three froms of DNA
Name the forces in DNA
H bonds between bases, hydrophobic bases in the middle, phosphates near water, stacking of bases (Van der Waals)
Functions of Nucleic Acids include:
Information molecules (DNA, RNA), Energy Metabolism (ATP), Anabolism (UDP-Glucose),
This is:
This is: