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13 Cards in this Set
- Front
- Back
PGE1 - treatment?
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treats impotence
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PGI3 - treatment?
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potent antiplatelet agent
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NSAIDS
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aspirin (acetyl salicylic acid)
cyclooxygense1 + aspirin = inactive **other NSAIDS = acetaminophen, ibuprofen, indomethacin NSAIDS = cause gastric bleeding and impaired clotting |
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Corticosteroids
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Inhibit phospholipase A2 & COX-2
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Selective COX-2 inhibitors
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only inhibit COX-2 (inflammation) not COX-1
ie. VIOXX (can increase risk of heart attack and stroke) |
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PGI2
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prostacyclin from PGH2
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PGF2α & PGE2
**PGE2 can also ripen the cervice |
causes uterine contraction
**used in induction of labour and abortion |
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LTB4 <- LTA4 <- 5-HPETE
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increased chemotaxis of WBCs
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cysteinyl leukotrienes
(LTC4 -> LTD4 -> LTE4) |
for:
*bronchoconstriction *vasoconstriction *increased vascular permiability *slow reacting substances of anaphylaxis (SRS-A) |
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anaphylaxis
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wide spread vasodilation & increased capillary permability => leads to circulatory shock
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asthma
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allergen-antibody rxn occurs in bronchioles of the lungs
*mast cells release SRS-A which causes spasm of bronchiolar smooth muscle |
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Tx of asthma
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corticosterois
leukotriene modifiers |
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leukotriene modifiers
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1) leukotriene synthesis inhibitor (inhibits 5-lipooxygenase)
2) leukotriene receptor antagonist (block receptors of cyteinyl leukotriene in smooth muscle) |