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13 Cards in this Set

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PGE1 - treatment?
treats impotence
PGI3 - treatment?
potent antiplatelet agent
NSAIDS
aspirin (acetyl salicylic acid)

cyclooxygense1 + aspirin = inactive


**other NSAIDS = acetaminophen, ibuprofen, indomethacin

NSAIDS = cause gastric bleeding and impaired clotting
Corticosteroids
Inhibit phospholipase A2 & COX-2
Selective COX-2 inhibitors
only inhibit COX-2 (inflammation) not COX-1

ie. VIOXX (can increase risk of heart attack and stroke)
PGI2
prostacyclin from PGH2
PGF2α & PGE2

**PGE2 can also ripen the cervice
causes uterine contraction

**used in induction of labour and abortion
LTB4 <- LTA4 <- 5-HPETE
increased chemotaxis of WBCs
cysteinyl leukotrienes

(LTC4 -> LTD4 -> LTE4)
for:
*bronchoconstriction
*vasoconstriction
*increased vascular permiability
*slow reacting substances of anaphylaxis (SRS-A)
anaphylaxis
wide spread vasodilation & increased capillary permability => leads to circulatory shock
asthma
allergen-antibody rxn occurs in bronchioles of the lungs

*mast cells release SRS-A which causes spasm of bronchiolar smooth muscle
Tx of asthma
corticosterois

leukotriene modifiers
leukotriene modifiers
1) leukotriene synthesis inhibitor (inhibits 5-lipooxygenase)

2) leukotriene receptor antagonist (block receptors of cyteinyl leukotriene in smooth muscle)