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20 Cards in this Set

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pyrimadines
CUT
CUT the PY
purines
AG
PUR As Gold
PRPP synthetase
enzyme in first step of pur & pyr synthesis, converts ribose-5 phosphate to PRPP
more metabolic diseases associated with ______ metabolism
purine
hydroxyurea
an antineoplastic agent that works on ribonucleotede reductase enzyme and inhibits pyrimidine synthesis
drugs - methotrexate (chemo), trimethotrim (antibiotic), & pyramethamine act on what enzyme
dihydrofolate reductase in pyrimadine synthesis
5 FU acts on ______ enzyme in the production of ________
thymidylate synthase in pyrimadines synthesis
Orotic Aciduria
elevated blood levels of orotic acid with NO associated hyperammonemia
Inosine
hypoxanthine + Ribose
PRPP Amidotransferase
important enzyme in purine synthesis inhibited by AMP, GMP, (nucleotides) & IMP (inosine monophosphate)
HGPRT’ase Defeciency
Decrease in the nucleotide pool
results in decreased feedback inhibition
of PRPP Glutamine Amidotransferase;
thus, increased nucleotide synthesis
and increased degradation which
elavates uric acid levels
causing uric acid crystal formation.
What disease is associated with Adenisine deaminase
SCID (severe combined immunodeficiency
What diseases is associated with HGPRT
-Lesch-Nyhan Syndrome
-gout
- hypouricemia
What percent of nucleotides go through salvage pathway
90%
Lesch-Nyhan Syndrome
-CP
-self mutilization
-hyperuricemia
-early death
HGPRT (HPRT) is associated with what pathway
salvage pathway
HGPRT deficiency
X linked recessive
shows up in males
young boys (lesch-nyhan) and old men (gouty arthritis)
How do you treat HGPRT defeciency
inhibitor of Xanthine Oxidase (because Xanthine more soluable than uric acid)
drug used to inhibit xanthine oxidase
allopurinol
6 mercaptopurine
anti-neoplastic