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20 Cards in this Set
- Front
- Back
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pyrimadines
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CUT
CUT the PY |
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purines
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AG
PUR As Gold |
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PRPP synthetase
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enzyme in first step of pur & pyr synthesis, converts ribose-5 phosphate to PRPP
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more metabolic diseases associated with ______ metabolism
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purine
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hydroxyurea
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an antineoplastic agent that works on ribonucleotede reductase enzyme and inhibits pyrimidine synthesis
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drugs - methotrexate (chemo), trimethotrim (antibiotic), & pyramethamine act on what enzyme
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dihydrofolate reductase in pyrimadine synthesis
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5 FU acts on ______ enzyme in the production of ________
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thymidylate synthase in pyrimadines synthesis
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Orotic Aciduria
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elevated blood levels of orotic acid with NO associated hyperammonemia
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Inosine
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hypoxanthine + Ribose
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PRPP Amidotransferase
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important enzyme in purine synthesis inhibited by AMP, GMP, (nucleotides) & IMP (inosine monophosphate)
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HGPRT’ase Defeciency
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Decrease in the nucleotide pool
results in decreased feedback inhibition of PRPP Glutamine Amidotransferase; thus, increased nucleotide synthesis and increased degradation which elavates uric acid levels causing uric acid crystal formation. |
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What disease is associated with Adenisine deaminase
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SCID (severe combined immunodeficiency
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What diseases is associated with HGPRT
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-Lesch-Nyhan Syndrome
-gout - hypouricemia |
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What percent of nucleotides go through salvage pathway
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90%
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Lesch-Nyhan Syndrome
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-CP
-self mutilization -hyperuricemia -early death |
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HGPRT (HPRT) is associated with what pathway
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salvage pathway
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HGPRT deficiency
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X linked recessive
shows up in males young boys (lesch-nyhan) and old men (gouty arthritis) |
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How do you treat HGPRT defeciency
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inhibitor of Xanthine Oxidase (because Xanthine more soluable than uric acid)
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drug used to inhibit xanthine oxidase
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allopurinol
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6 mercaptopurine
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anti-neoplastic
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