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27 Cards in this Set
- Front
- Back
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where are the enzymes for ppp located?
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cytosol
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is there any ATP produced in the ppp?
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no
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what is the electron acceptor for ppp?
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NADP
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where does the NADPH go?
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other biosynthetic pathways
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is the oxidative phase reversible?
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no
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is the non-oxidative phase reversible?
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yes
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the non-oxidative phase links to what?
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glycolysis and gluconeogenesis
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What is the very important enzyme for NADP?
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glucose-6-dehydrogenase
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what is the rate-limiting step of ppp?
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glucose-6-dehydrogenase
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decarboxyilation does what?
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makes a 5 carbon
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the enzyme pentose p isomerase converts what to what?
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glucose 6 p to ribulose 6 p
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ribose-5 P is eperimized to xyulose-5-p via?
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phosphopentose isomerase
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what are the end products of PPP?
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glceraldehyde-3-P and fructose-6-P
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What are the two enzymes thagt convert the xyluose to G3P and fructose-6-P?
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transketose and transaldose
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What vitamin and cmpd do you need for transketolase?
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thiamine-PP (B1) and Mg2+
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The complete oxidation of glucose 6 P ->
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6CO2 + 12 NADPH + 12 H+
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how many cycles are required for the complete oxidation of the PPP?
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6 to get 6 CO2's
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What is the regulatory enzyme of PPP?
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glucose-6-dehydrogenase
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What activates the PPP?
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high NADP+/NADPH ratio
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What stops the PPP?
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ribose-5-p
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glyceraldehyde can link to the glycolidic pathway via?
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DHAP
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What is the major function of the glutathione and the PPP?
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to protect against toxic reactive oxygen species- antioxidant
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What must the glutathionen and PPP be reduced from/to?
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G-SH to function- NADHP is needed
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G-SH acts as a coenzyme for?
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glutathione peroxidase
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Glutathione reductase regulates?
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G-SH
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hemolytic anemia is caused by a deficiency in what?
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glucose-6-DHASE... decrease in NADPH
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what two things does the PPP need?
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NADPH and ribose-5-P
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