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11 Cards in this Set
- Front
- Back
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What is the rate limiting and irreversible step in glycolysis?
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when PFK-1 is used to convert fructose 6 phosphate to fructose 1,6 bisphosphate
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What inhibits the rate limiting step of glycolysis, effectively downregulating glycolysis?
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citrate accumulates from TCA cycle not being able to continue (due to high levels of ATP) and leaks into cytosol, inhibiting PFK-1. This stops glycolysis
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Arsenate inhibits what step in glycolysis?
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GAP to 1,3-BPG using glyceraldehyde 3 phosphate dehydrogenase
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When is the only NADH produced in glycolysis?
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GAP to 1,3-BPG using glyceraldehyde 3 phosphate dehydrogenase. THINK DEHYDROGENASE
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When is the 1st ATP produced in glycolysis?
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1,3-BPG converted to 3-phosphoglycerate using phosphoglycerate kinase
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what converts 2-phosphoglycerate to PEP?
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enolase
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What inhibits enolase?
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fluoride
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PEP is finally converted to pyruvate using ___________.
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pyruvate kinase
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when is the second and last ATP produced?
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last step, pyruvate kinase making pyruvate
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What enzyme makes lactate from pyruvate and NADH?
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lactate dehydrogenase
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What is PFK-2?
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Activates PFK-1, which is the rate limiting step for glycolysis (activates glycolysis).
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