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25 Cards in this Set
- Front
- Back
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2s of Meckel diverticulum
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2 year
2 organs 2 feet from ileocecal calve 2% of population 2 inches in size |
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glycolytic enzyme deficiency
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hemolytic anemia
-inability to maintain Na/K ATPase -swelling and lysis |
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MC glycolytic enzyme deficiency
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pyruvate kinase
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muscle biopsy shows elevated glycogen, elevated F6P and decreased pyruvate
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PFK-1 deficiency
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what allosterically activates PFK-1
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F2,6BP
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how do levels of F2,6BP change in the liver and muscle during sympathetic response
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muscle
-inc F2,6BP-more PFK-1 liver -dec F2,6BP-less PFK-1 |
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what are the irreversible enzymes of gluconeogenesis
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PEP carboxykinase
F16BP G6P Pyruvate carboxylase |
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difference between glucokinase and hexokinase
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glucokinase
-liver and B cells -stimulated by insulin hexokinase -everywhere -not stimulated by insulin |
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glycogen storage disease:
glycogen phosphorylase def |
mcardle
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glycogen storage disease:
G6P def |
von gierks
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glycogen storage disease:
lactic acidosis, hyperlipidemia, hyperuricmemia |
von gierks
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glycogen storage disease:
a-1,6 glucosidase def |
cori
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glycogen storage disease:
a-1,4 glucosidase def |
pompe
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glycogen storage disease:
cardiomegaly |
pompe
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glycogen storage disease:
diaphragm weakness |
pompe
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glycogen storage disease:
increased glycogen in liver, severe fasting hypoglycemia |
von gierks
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glycogen storage disease:
hepatomegaly, hypoglycemia, hyperlipidemia (normal kidneys, lactate, uric acid) |
cori
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glycogen storage disease:
painful muscle cramp, myoglobinuria with strenuous exercise |
mcardle
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glycogen storage disease:
severe hepatosplenomegaly, enlarged kidneys |
von gierks
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ATP produced by anaerobic glycolysis
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2
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ATP produced by aerobic glycolysis
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malate aspartate
-32 G3P -30 |
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what feedback inhibits hexokinase
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G6P
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what does pyruvate carboxylase require to work
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ABC
activated by acetyl CoA |
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what inactivates glycogen phosphorylase
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insulin
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what activates glycogen phosphorylase
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glucagon
epi |
