Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
what makes carbomyol phosphate?
|
ATP
glutamine CO2 |
|
|
rate limiting step in pyrimidine synthesis?
|
CPS2 in cytosol
|
|
|
moa of hydroxyurea?
|
blocks ribonucleotide reductase
tx of sickle cell to increase HbF |
|
|
moa of 5-fluouracil ?
|
blocks thymidylate synthase
|
|
|
moa of trimetoprim?
|
block bacterial dihydrofolate reductase
|
|
|
moa of methotrexate?
|
block dihydrofolate reductase
|
|
|
drugs that block dihydrofolate reeducates?
|
trimethoprime
pyrimethamine methotrexate |
|
|
moa of 6-mercaptopurine?
|
blocks PRPP synthesis to block de novo purine synthesis
|
|
|
rate limiting step of purine synthesis?
|
glutamine PRPP amindotransferase
|
|
|
orotic aciduria?
cause? genetics? findings? treatment? |
can't convert orotic acid to UMP
AR increase orotic acid in urine megaloblastic anemia --> doesn't improve w/ B12 or folic acid failure to thrive NO hyperammonemia treatment = oral uridine administration |
|
|
DNA mutation w/ amino acid deletion?
|
fram shift
|
|
|
what prevents strings from reannealing?
|
single stranded binding proteins
|
|
|
what creates a nick in helix to relieve supercoild created during replication?
|
DNA gyrase/topoisomerase
|
|
|
disorder that prevents repair of thymidine dimers?
|
xeroderma pigmentosum
don't have nucleotide excision repair AR |
|
|
what is damaged to cause cytosine deamination?
|
base excision repair
|
|
|
alpha amanitin blocks what? causes what? found where?
|
blocks RNA polymerase II
found in death cap mushrooms causes liver failure if injested |
|
|
where does RNA polymerase I make rRNA
|
nucleolous
|
|
|
what type of RNA polymerase opens DNA at promoter site?
|
RNA Polymerase II
|
|
|
RNA processing steps?
|
capping on 5' end
polyadenylation on 3' end --- AAUAAA polyadenlyation signal - not transcribed from DNA splicing out of introns hnRNA = initial capped + tailed = mRNA |
|
|
what disease makes antibodies to spliceosomal snRNPs?
|
lupus patients
|
