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35 Cards in this Set
- Front
- Back
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Anti Endomysial Ab
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celiac disease
|
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abdominal pain, normal WBC, no fever. parasthesias of lower extremities
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AIP
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Where are stem cells located
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skin
hair GI BM Canal of hering dentate gyrus |
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RLS of purine synthesis
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PPRP aminotransferase
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RLS of pyrimidine synthesis
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CPS2
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carbon source for purines
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CO2
THF Glycine |
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carbon source for pyrimidines
|
CO2
aspartate |
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which medication:
inhibits ribonucleotide reductase |
hydroxyurea
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which medication:
inhibits DHF reductase |
methotrexate
trimethoprime pyrimethamine |
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which medication:
inhibits thymidylate synthase |
5FU
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which medication:
inhibits IMP DH |
ribaviron
mycophenolate |
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which medication:
inhibits PRPP synthetase |
6MP
|
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characteristics of orotic aciduria
|
inc orotic acid
no ammonia megaloblastic anemia -not corrected by B12 or Folate |
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which eukaryotic DNA polymerase replicates lagging strand
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a
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which eukaryotic DNA polymerase repairs DNA
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B
E |
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which eukaryotic DNA polymerase replicates mitochindrial DNA
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y
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which eukaryotic DNA polymerase replicates leading strand
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g
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what makes heterochromatin transcriptionally inactive
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methylation
converts cytosine to methylcytosine |
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what adds TTAGGG repeats to the 3' end
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telomerase
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what are the 2 subunits of telomeres
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TERT
-reverse transcriptase TERC -RNA template |
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nitrogen sources for purines
|
glycine
glutamine aspartate |
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treatment for hairy cell leukemia
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cladribine
|
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MOA of cladribine
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purine analog
resistant to degradation by ADA |
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MOA of pentostatin
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purine analog
irreversible inhibitor of ADA |
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what accumulates in lesch nyhan syndrome
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hypoxanthine
guanine |
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what accumulates in SCID
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adenosine
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MOA of DNA polymerase 1
|
degrade RNA primer
5'-3' exonuclease |
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MOA of DNA polymerase 3
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5'-3' synthesis
3'-5' exonuclease |
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what makes up the primasome
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helicase
primase |
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what does primase do
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makes RNA primer
-gets incorporated into uracil |
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what are the two types of topoisomerase
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1=relieves super coils
2=causes breaks |
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diseases a/w DNA repair defects
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XP
ataxia telangiectasia blooms syndrome HNPCC BRCA 1/2 |
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defect in XP
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nucleotide excision repair defect
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defect in HNPCC
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mismatch repair defect
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what is mutated in HNPCC
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MSH2
MLH1 |
