Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
37 Cards in this Set
- Front
- Back
List the 5 stages of haemostasis
|
.
|
|
Describe the different stages og haemostasis
|
.
|
|
Explain how injured blood vessels constrict
|
.
|
|
Describe the process of platelet plug formation
|
.
|
|
List the factors affecting platelet plug formation
|
.
|
|
Define blood coagulation
|
.
|
|
Explain the intrinsic, extrinsic, and common pathways
|
.
|
|
Describe the interrealtionship between clotting factors
|
.
|
|
Explain the relationship between vitamin K and heamorrhagic disorders
|
.
|
|
Explain how vitamin K enables certain proteins bit bind calcium ions
|
.
|
|
List four disorders of homeostasis
|
.
|
|
Explain the different causes of disorders of coagulation
|
.
|
|
Define haemostasis
|
.
|
|
List the stages of haemostasis
|
.
|
|
Briefly describe the stages of haemostasis
|
.
|
|
Discuss the activation of blood clotting factors
|
.
|
|
Briefly outline the process of coagulation
|
.
|
|
Distinguish between the intrinsic, extrinsic, and common pathways of coagulation
|
.
|
|
Explain the role of vitamin K in blood clotting
|
.
|
|
Briefly explain disorders of haemostasis.
|
.
|
|
Define haemostasis
|
The maintenance of blood within the blood vessels
|
|
What are the five stages of haemostasis?
|
1. Constriction of injured blood vessel
2. platelet plug formation 3. clot formation 4. clot retraction 5. clot dissolution |
|
what is the circulating glycoprotein which helps form links between platelets and exposed collagen?
|
vWF attaches to collagen when endothelial cells are damaged. vWF also carries factor VIII
|
|
Describe the function of prostacyclin in platelet aggregation
|
is released from healthy blood endothelial cells to prevent platelet aggregation. Damage prevents prostacyclin production, thus allowing platelet aggregation.
|
|
What two substances released from platelets have a positive feedback effect on platelet morphological change?
|
ADP, thromboxane A2
|
|
What are the functions of factor V and factor XIII?
|
Factor V is essential for activation of the common pathway and factor XIII essential for crosslinking of fibrin fibres
|
|
Briefly describe the role of serotonin in haemostasis
|
serotonin acts as vasoconstrictor, thus reducing blood flow to the injured area.
|
|
How does a blood clotting factor relate to its activated counterpart?
|
each factor is a zymogen or enzyme precursor. Activation usually involves changes to the zymogen to produce an active enzyme.
|
|
Define coagulation
|
Coagulation is the formation of a blood clot; a mesh of fibrin and blood cells
|
|
What substance is required to stabilize fibrin?
|
activated factor XIII (fibrin stabilizing factor)
|
|
which amino acid does vitamin K affect?
|
glutamate (glutamic acid)
|
|
what is the new amino acid formed by vitamin K action?
|
gamma-carboxyglutamate
|
|
in which organ does vitamin K exert its action?
|
liver
|
|
List two vitamin K analogues
|
dicoumarol; warfarin
|
|
List four disorders of haemostasis
|
Haemophilia B
Thrombocytopaenia Thrombocytopathia Von Willebrands disease |
|
Name three disorders of platelet functions
|
Thrombocytopaenia
Thrombocytopathis Von Willebrands disease |
|
what mineral is needed for blood clotting?
|
calcium
|