Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Bio17: What is the end result of telomerase activity for a given cell?
|
Immortality
|
|
|
Bio17: Where do BCL2 and BAX act?
|
Mitochondria
Endoplasmic reticulum |
|
|
Bio17: Apoptosis vs necrosis
|
Bio17: Apoptosis vs necrosis
|
|
|
Bio17: What comprises APAF-1?
|
Bio17: What comprises APAF-1?
|
|
|
Bio17: Hydroxyurea
|
Synchronizes cells at G1/S
|
|
|
Bio17: Cyclins
|
No intrinsic enzymatic activity
Cyclins A to J identified Syntehsized and degraded with each cell cycle phase Growth factors induce cyclins in G1 Bind and activate CDKs |
|
|
Bio17: CDKs
|
Cyclin Dependent Kinases
-Serine/threonine kinases -Present throughout cell cycle -Have multiple substrates |
|
|
Bio17: Activating phosphatases
|
CDC25A on cyclin E/CDK2:G1/S specific
CDC25B on cyclin A/CDK2:S exit CDC25C on cyclinB/CDK1:G2/M specific |
|
|
Bio17
Cell cycle phase:Cyclin/CDK complex |
G1 : Cyclin D/CDK4,6
G1/S Arrest : Cyclin E/CDK2,3 S Arrest : Cyclin A/CDK2 G2/M Arrest : Cyclin B/CDK1 |
|
|
Bio17: Cell cycle control diagram
|
Bio17: Cell cycle control diagram
|
|
|
Bio17: What is needed for mitosis?
|
MPF
|
|
|
Bio17: Ras pathway
|
Ras --> Raf --> Mek
|
|
|
Bio17: What are two types of DSB repair in mammals and which predominates?
|
NHEJ and HR
NHEJ predominates HR occurs when there are sister chromatids |
|
|
Bio17: What is NF-kB?
|
Bio17: What is NF-kB?
|
|
|
Bio17: Compare ras and c-myc
|
Ras - activated by point mutation
c-myc - Activated by translocation |
|
|
Bio17: Which cycln/CDK pair is responsible for entering mitosis? G1? G2?
|
Mitosis: cycB/CDK1
G1: cycD/CDK46 G2: cycA/CDK12 |
|
|
Bio17: MDM2 effect on p53
|
Bio17: MDM2 effect on p53
|
|
|
Bio17: Consequences of mutant p53 expression
|
Increased genomic instability
Decreased apoptosis Increased tumor aggressiveness Increased level pf p53 Decreased radiosensitivity |
|
|
Bio17: What is the connection between RB and E2F?
|
Bio17: What is the connection between RB and E2F?
|
|
|
Bio17: What is the function of DNA PK?
|
Bio17: What is the function of DNA PK?
Involved in VDJ recomb of immunoglobulin genes Makes cell very radiosensitive |
|
|
Bio17
How does HNPCC occur? Which molecule is involved? |
Mismatch repair
MSH |
|
|
Bio17: Who does mismatch repair?
|
MSH2-MSH6
|
