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68 Cards in this Set

  • Front
  • Back

GLUT5

Import of fructose to enterocytes of small intestine from lumen

SGLT-1

Na+-glucose transport #1 fo glucose and galactose import to enterocytes from lumen

GLUT2

Glucose transport into enterocytes at high glucose levels from lumen

Basal side of enterocyte

GLUT2 and GLUT5 for efflux of glucose and fructose

Apical side of enterocyte

SGLT1 and GLUT5 for import of glucose, galactose and fructose

PEPT1

transports di and tripeptides into enterocytes on apical side

9 essential amino acids

K,V,I,L,W,F,M,T,H

Vit A fxns

Vision and gene regulation

Vit A deficiency

Night blindness, epithelial damage

Vit D, Calciferol fxn

Calcium and phosphate absorption

Vit D deficiency

Ricketts

Vit C, ascorbic acid fxn

Antioxidant, connective tissue

Biotin fxn

Coenyme

Biotin deficiency

hair loss, skin problems

Vit K fxn

Blood clotting (menadione)

Vit K deficiency

hemophilia

Vit E fxn

Antioxidant

Vit E deficency

anemia (free radicals)

Simple lipids

Fatty acids, triaglycerol, sterols (cholesterol)

Complex

Phospholipids, Lipoproteins

Triaglycerides

Glycerol backbone + 3 fatty acid chains linked by ester bond

Enzyme breaking own triaglyceride

Lipases

Transport of short chain FA and glycerol

Through blood

Transport of long chain FA, monacylglycerides, triglycerides, and cholesterol

Through ER as chylomicrons, packed in golgi and secreted to lymph

Glycerol

3 Carbon methylene with hydroxyls

sn2monoacylglycerol

acyl fatty acid on middle glycerol carbon

What is the gut derived from

Endoderm

3 main regions of the gut

Foregut, midgut, hindgut

What make up the foregut

Esophagus, stomach, anterior duodenum and it forms the buds for the liver and pancreas

WHat make up the midgut

The posterior part of duodenum, jejunum, ileum, cecum and large intestine

Hindgut?

Colon and rectum

How do you increase uptake at the lumen of GI tract (of nutritents)

increase surface area

2 ways that the GI tract has increased surface area

Long gut length, surface undulations (with folds, microvilli, and villi)

What are villi

Entereocytes lined with microvilli (brush border)

Cells in stomach

Mucous, chief, parietal, entereoendocrine

What do mucous cells secrete

bicarbonate and muscin

What does bicarbonate in the stomach do

Buffer the pH of the stomach for a moer gradual gradient

What does muscin in the stomach do

It is a glycoprotein which is a gel like matrix

What do chief cells do

They secrete protease pepsin

What do enteroendocrine cells do

Secrete hormones into the blood (gastrin)

What do parietal cells do

Excrete HCl, stimulated by hormones

Layers of the stomach

Mucousa, submucosa, smooth muscle

Layers of the intestine

Mucosa, submucosa, circular smooth muscle, longitudinal smooth muscle

Cells in intestines

Entereocytes, goblets, enteroendocrine, pareth, crypt of liberkuhn

What do enterocytes in the intestine do?

Absorption

What do Goblet cells in intestine do?

secrete mucus

What do enteroendocrine cells in intestine do?

Secrete hormones

What do pareth cells in the intestine do?

Secrete antimicrobials like lysozymes

What do Crypt of Liberkuhn do?

Secrete sucrase, maltase, lactase, peptidase

What do the longitudinal muscles of intestine do?

Control length and peristalsis

What do the circular muscles of intestine do?

Control diameter and segmentation

Where is the origin of contraction signals?

Myogenic and neurogenic

What is the etwork between muscle layers called?

Mytenic plexus

What innervation is in the mytenic plexus?

Both para and sympathetic

What do bile salts do?

Help emulsify fat

Hormones for short term info about hunger

Ghrelin, CKK, PYY, (from vagus?)

Hormones for long term info about hunger

leptin

POMC neuron more hungry or less

Decrease appetite

NPY neuron more hungry or less

Stimulate appetite

Ghrelin effect

stimulate relase of NPY

CKK

Inhibit NPY (which then allows POMC to be active)

PYY

Inhibit NPY

Leptin

Inhibit NPY and also activate POMC

What part of hypothalamus has receptors for appetite hormones

Arcuate nucleus

Where is leptin from

white adipose tissue

where is ghrelin from

stomach

where is ckk from

duodenum

where is pyy from

colon