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9 Cards in this Set
- Front
- Back
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how is postsynaptic muscle mmb organized?
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jnal folds to increase area and concentrate receptors at the synapse
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what type of receptor is nAChR?
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channel-linked receptor; binding ACh opens non-selective cation channel for K+ and Na+, increasing gNa/gK = 1.4
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What is Er for nAChR?
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-15mV
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what does end plate refer to?
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muscle mmb
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2 competitive inhibitors of nAChR
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alpha-bungarotoxin (almost irreversible), curare
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what does atropine block
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high [] - mAChr
low [] - nAChr |
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e.g. ligand gated ion channel?
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Serotonin (5-HT) to HT3R
glutamate to glutamic R ATP to P2XR all non-selective cation channel all Er = 0 all these ligands = excitatory |
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inhibitory ligands?
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GABA
glycine |
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which patch clamp methods can be used to study molecular property of channels?
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outside out and cell attached
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