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18 Cards in this Set
- Front
- Back
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What is the difference between Thiamn B1 and Thiamin Pyrophosphate (TPP) Active B1?
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Thiamin Pyrophosphate (TPP) Active B1 has two phosphate groups.
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What is the reactive group in Vitamin B1?
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Thiazole Ring
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What type of reaction is Vit B1 usually involved in? Give an example.
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Decarboxylation Reaction. An example is pyruvate dehydrogenase.
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Transketolase Reaction (TK) requires ________.
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TPP ( Active B1)
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How do you test TK Activity?
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Vary B1 in diet --> RBC --> Protein Extract --> Assay TK +/- TPP
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Draw graphs for deficient levels of TPP, sufficient levels of TPP, and Diabetics.
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Blank.
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Why do diabetics show sufficient levels of TPP but show adverse effects?
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Diabetics excretes TPP 15x higher. TPP levels in blood of diabetics is 75% lower. There is an increased upregulation of TPP in diabetics.
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What is a Vit B1 related disease? Name 2 Symptoms.
What portions of the body does it affect? What sort of diet do people who get this disease usually eat? |
Beriberi. Patient is very weak, thin, loss of short-term memory. The portion of the body affected is the CNS and GI- organs with high level consumption. The diet usually consists of 80% refined grains.
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Alcohol _______ B1 absorption and ________ B1 excretion.
What is Wenicke-Korsakoff Syndrome? What are some symptoms? |
inhibits, stimulates. WKS in alcoholics due to thiamin deficiency. Symptoms include gait, derangement, and eye trouble
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What is the difference between Vit B2 Riboflavin and FAD?
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FAD is the active form. FAD ox <-> FADH2 red
FAD is the more complicated looking structure. |
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When do symptoms of Vit B2 Riboflavin deficiency develop? Name 2 Symptoms.
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Inflammation of throat, anemia, fatigue
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Draw the reduced form of Vit B3 Niacin.
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Hexane structure with N-R on the bottom. Two double bonds on the side with CONH2 sticking out from the top right double bond.
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Draw the oxidized form of Vit B3 Niacin.
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Hexane structure with N-R on the bottom. Three double bonds starting with the left from the bottom and having a CONH2 at the start of the second double bond.
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When do symptoms of Niacin Deficiency start to appear? What is the main symptom?
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2 months after deficiency. Pellagra meaning broken skin.
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What happened in the Pellagra Epidemic in the US?
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During the early 1900s, people were suffering from Pellagra due to their diet of mostly corn, salt pork and black eye peas. Salted pork had little niacin and corn has a lot of niacin. However, niacin in corn is inaccessible unless it is treated with lime water (alkaline). Corn treated with lime water and addition of eggs, meat, and milk helped treat this epidemic.
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Describe Niacin treatment of Atherosclerosis.
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1.5-2 gm/day decreases LDL and increases HDL.
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What is the difference between Vit B6 Pyridoxal and active form Pyridoxal Phosphate (PLP)?
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PLP has the phosphate group attatched to its side.
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What is the reactive group of both the Pyridine derivative and the active form?
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Aldehyde group. CHO.
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