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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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how do beta lactams work?
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cell wall synthesis inhibition via interfering with transpeptidation run
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what is bacterial cell wall composed of?
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polysaccharides containing alternating amino sugars of N-acetylglucosamine and N-acteylmuramic Acid
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there is a 5 aa peptide that attaches to the NAMA-- terminates in D-alany-D-alanine
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what does PBP do?
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Penicillin-bidning protein--removes terminal alanine
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what replaces the terminal alanine?
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beta-lactam antibiotics
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what does this do?
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inhibits the transpepidation rxn--halts peptidoglycan synthesis, and cell dies
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what do beta lactams need in order to work?
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for cells to be actively growing and synthesizing cell wall
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