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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Acebutolol (MOA & PK)
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MOA - More selective at beta-1 with partial agonist activity, anesthetic effects
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PK - PO; low lipid solubility; good bioavailability; half-life 5 hours
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Acebutolol (CU & T)
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CU - Hypertension; angina
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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Bisoprolol (MOA & PK)
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MOA - Beta-1 specific antagonist
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PK - Long duration
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Bisoprolol (CU & T)
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CU - Hypertension; angina
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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Betaxolol (MOA & PK)
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MOA - Beta-1 specific antagonist
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PK - PO/ophthalmic; long duration; half-life 14-22 hours
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Betaxolol (CU & T)
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CU - Topical glaucoma treatment
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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Esmolol (MOA & PK)
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MOA - Beta-1 specific antagonist
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PK - IV; very short half-life (minutes)
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Esmolol (CU & T)
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CU - Supraventricular arrhythmias; peri-operative hypertension, MI
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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Atenolol (MOA & PK)
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MOA - Beta-1 specific antagonist
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PK - PO; low lipid solubility; half-life 6-9 hours
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Atenolol (CU & T)
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CU - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung and endocrine effects than propranolol; may be better for patients with asthma, COPD and diabetes
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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Metoprolol (MOA & PK)
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MOA - Beta-1 specific antagonist
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PK - PO; moderate lipid solubility; half-life 3-4 hours
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Metoprolol (CU & T)
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CU - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung and endocrine effects than propranolol; may be better for patients with asthma, COPD and diabetes
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T - Bronchoconstriction, bradycardia, negative inotropy, hypotension, arrhythmias, sedation, depression, reduce recovery from hypoglycemia, withdrawal may occur, impotence; less lung effect compared to propranolol
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