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11 Cards in this Set

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BDZ administered i.m. or i.v.
Chlordiazepoxide
Chlorazepate
Diazepam
Midazolam
Lorazepam
BDZs T1/2
Long (>1 day): flurazepam, chlordiazepoxide, clorazepate, diazepam
Intermediate (6-24 hrs): temazepam
Short (<6 hrs): triazolam
Benzodiazepines
Mechanism: positive allosteric of GABA

Clinical Use: Anxiloytic effect, sedation, muscle relaxant, anticonvulsant, hypnosis

Side Effects: Ataxia, Sedation, tolerance (not to anxiolytic effects), psychological dependence, short T1/2= withdawal symptoms
Flurazepam
Mechanism: benzodiazepine, long T1/2

Clinical Use: Insomnia

Side Effects: impaired driving, tolerance after 3 wks
Temazepam
Mechanism: benzodiazepine, intermediate T1/2

Clinical Use: Insomnia

Side Effects: impaired driving at high dose
Triazolam
Mechanism: benzo, short T1/2

Clinical Use: initial insomnia

Side Effects: some wake up early and can't go back to bed, heightened anxiety following day
Alprazolam
Clonazepam
Lorazepam
Mechanism: benzo, long T1/2

Clinical Use: Anxiety with automnomic signs e.g. panic disorder, agoraphobia
Midazolam
Lorazepam
Preanesthetic
Clonazepam
Abscence seizures
Flumanezil
Mechanism: BDZ antagonist

Clinical Use: reversal of BDZ effect durign general anesthesia, overdose

Side Effects: may precipitate withdrawal
Buspirone
Mechanism: partial 5-HT1A agonist

Clinical Use: non-sedative anxiolytic, not as effective as BDZ in severe anxiety

Side Effects: no withdrawal, well tolerated