Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
3 Cards in this Set
- Front
- Back
|
Benzodiazepines- Physiochemical
|
Diazepam, Midazolam and lorazepam all used in OR for anxiolysis and anterograde amnesia
Midazolam is most lipophilic |
|
|
Benzodiazepines- Pharmacokinetics
|
High lipid solubility leads to rapid CNS onset
Redistribution leads to termination Metabolism in liver via oxidation which is susceptible to degradation with age and cirrhosis (midazolam, diazepam) -Midazolam --> metabolized to inactive metabolite (short context sensitive h/t) (can be used continuous inf) -Diazepam --> metabolized to active metabolite (prolonged elimination half time) |
|
|
Benzodiazepines- Pharmacodynamics
|
MOA- activation of GABAa receptor complex --> increased Cl current --> hyperpolarization --> reduced excitability
GABAa receptors responsive to benzos occur almost exclusively in the cerebral cortex (minimal effects outside CNS) (lower vent dep and hypotension) CNS - sedative hypnotic and anterograde amnesia |
