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28 Cards in this Set
- Front
- Back
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what is the leser-trelat sign? which neoplasm is it associated with?
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sudden explosive growth in lg #'s due to GI malignancy
SK |
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sharply demarcated greasy papule or plaque
"pasted on" crumbly/ verrucous surface keratin-filled pit |
seborrheic keratosis (SK)
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exophytic lesion
sheets of small cells (resemble basal cells) variable pigmentation hyperkeratosis keratin-filled cysts |
SK
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how is SK diagnosed?
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shave biopsy
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soft papules attached by slender stalk
esp in axilla, neck, eyelids, intertriginous areas |
fibroepithelial polyp (skin tag)
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multiple epidermal cysts on face, scalp, back
Gardner Sd assoc |
epithelial inclusion cyst/ sebaceous cyst/ epidermoid cyst
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what is Gardner Sd?
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rare auto dom
assoc w/ FAP assoc w/ epithelial inclusion cysts |
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mobile, firm, domed nodule
central pore is follicle opening foul-smelling cheesy keratinous material in center |
epidermal inclusion cyst
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from outer root sheath of follicle at middle 1/3 (isthmus) of follicular canal
inheritance factor usually on scalp |
pilar cyst -- thicker wall than epidermal cyst
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smooth firm nodule on scalp
NO CENTRAL PORE foul-smelling cheesy keratinous material |
pilar cyst
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outer root sheat/ trichilemma of follicle
homogenous keratin inside focal calcification &/or cholesterol clefts rapid keratinization of squamous epithelium w/o granular layer |
pilar cyst
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tumors of follicles, sebaceous & sweat glands
papule or nodule |
adnexal tumor
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cylindroma
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adnexal tumor
ductal differentiation |
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syringoma
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adnexal tumor
eccrine differentiation |
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pilomatrixoma
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adnexal tumor
trichilemmal/ hairlike differentiation |
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tricholemmoma
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adnexal tumor
pilosebaceous follicular epithelium |
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sebaceous adenoma
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adnexal tumor
assoc w/ muri-torre sd (internal malignancy + sebaceous adenoma) |
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focal dermal fibrosis
overlying epidermal thickening hyperpigmentation women's legs |
dermatofibroma
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firm brown papule or nodule
flatter over time dimple sign |
dermatofibroma
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spindle-shaped cells
non-encapsulated mass mid-dermis epidermal hyperplasia downward elongated rete ridges |
dermatofibroma
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slow growing
locally aggressive primary fibrosarcoma |
dermatofibrosarcoma protuberans
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what genes are involved in dermatofibrosarcoma protuberans?
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balanced translocation:
COL1A1 PDGFB |
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radial arrangement of fibroblasts, like a pinwheel = storiform
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dermatofibrosarcoma
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button hole sign
neuromesenchymal tissue rubbery papule or nodule wavy Schwanna cells |
neurofibroma
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antoni A - dense areas
antoni B - loose areas spindle-shaped cells nuclei line up |
schwannoma
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vascular neoplasm
skin trauma & hormone assoc. often during pregnancy sudden onset younger people name makes no sense |
pyogenic granuloma
(not pyogenic or granulomatous) |
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domed papule or nodule
yellow to red head, neck, fingers GINGIVAL MUCOSA ESP IN PREGNANT |
pyogenic granuloma
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circumscribed
thinned epidermis new capilaries fibroblastic, edematous stroma epidermal collarette |
pyogenic granuloma
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