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14 Cards in this Set
- Front
- Back
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hyperactivity of dopamine in the mesolimbic tract is associated with what?
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+ psychotic sx
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traditional antipsychotics work by doing what?
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blocking D2 receptors and inhibit activity of dopamine
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traditional antipsychotics are most effective in txing what type of sx?
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positive
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low potency traditional antipsychotics
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chlorpromazine and thioridazine
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high potency traditional antipsychotics
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haloperidol, fluphenazine, trifluoperazine, perphenazine, pimozide
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what do low potency traditional antipsychotics block (3)?
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D2 receptors, muscarinic ACh receptors and histamine receptors
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SEs of low potency traditional antipsychotics?
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dry mouth, constipation, blurred vision, urine retention, weight gain, sedation
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SEs of high potency traditional antipsychotics
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extrapyramidal effects, neuroleptic malignant syndrome, tardive dyskinesia, decreased seizure threshold
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atypical antipsychotics
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clozapine, olanzapine, quetiapine, ziprasidone, aripiprazole
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where do atypical antipsychotics work?
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D2, 5-HT serotonin and noradrenergic receptors
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atypical antipsychotics are effective for what type of sx?
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both positive and negative
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how are negative sx improved with the use of atypical antipsychotics?
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block dopamine action in mesolimbic and increase its action in mesocortical
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which type of antipsychotic is likely to reduce the risk of relapse?
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atypical
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SEs of atypicals
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agranulocytosis, weight gain
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