Behavior Modifying Drugs

Front 1

Benzodiazepines

Back 1

Diazepam
Clorazepate

Front 2

Azapirones

Back 2

Buspirone

Front 3

Tricyclic antidepressants are

Back 3

SNRI's
Block serotonin and NE reuptake

Front 4

Tricyclic Antidepressants

Back 4

amitriptyline
Clomipramine

Front 5

SSRI's

Back 5

Fluoxetine
Paroxetine
selective serotontine reuptake inhibition

Front 6

MAOI's

Back 6

Monoamine oxidase inhibitor (catecholamines)
Selegiline

Front 7

MAOI's MOA

Back 7

antagonist of MAO-B, decreases dopamine metabolism

Front 8

Selegiline is used for

Back 8

cognitive dysfunction syndrome, pituitary dependent HAC and Cushings

Front 9

MAOI's net result

Back 9

increased dopamine

Front 10

Diazepam's MOA

Back 10

GABA agonist - increases GABA binding affinity, increasing Cl conductance into cell

Front 11

Benzodiazapine uses

Back 11

Anxiolytic - decrease storm anxiety, sedation, anti-convulsant, muscle relaxation, increase appetite, premed

Front 12

Benzodiazapine NT

Back 12

GABA - enhances Cl conductance, hyperpolarizes excitable membranes.

Front 13

Benzodiazapine Adverse Affects

Back 13

Toxicity - low
hepatic necrosis in cats
tolerance can develop with chronic use

Front 14

Buspirone MOA

Back 14

Full agonist at presynaptic and partial at post synaptic SHT - 1A agonsit =
decreases serotonin synthesis

Front 15

Buspirone is used for

Back 15

reducing cat urine spraying

Front 16

Amitriptyline MOA

Back 16

SNRI blocks serotonin and NE reuptake

Front 17

Amitriptyline uses

Back 17

separation anxiety in dogs, excessive grooming, spraying, anxiety in cats, reduce feather plucking in bird

Front 18

Amitriptyline NT

Back 18

increases serotonin and NE

Front 19

Amitriptyline adverse affects

Back 19

Alpha 1 antagonist, antihistaminic, anticholinergic, side effects from decreased secretions, dry mouth, sedation, constipation

Front 20

Buspirone Adverse Affects

Back 20

GI signs

Front 21

Clomipramine MOA

Back 21

blocks serotonin and NE uptake

Front 22

clmipramine uses

Back 22

Anxiolytic urine spraying in cats

Front 23

Clomipramine NT

Back 23

increases serotonin and NE

Front 24

Fluoxetine MOA

Back 24

inhibits serotonin reuptake

Front 25

Fluoxetine Uses

Back 25

Anxiolytic urine spraying in cats, psychogenic alopecia, aggression, stereotypic behavior
In dogs, anorexia, lethargy, anxiety irritability hyperactivity, aggressive behavior

Front 26

Fluoxetine NT

Back 26

increases serotonin

Front 27

Fluoxetine adverse affects

Back 27

sedation, anorexia, irritability, disinhibition
Don't use with patients with diabetes mellitus, patients with epilepsy, or seizures,

Front 28

Paroxetine MOA

Back 28

inhibits serotonin reuptake

Front 29

Paroxetine Uses

Back 29

Anxiolytic canine aggression

Front 30

paroxetine NT

Back 30

increases serotonin

Front 31

Paroxetine adverse affects

Back 31

dry mouth, sedation, GI upset, irritability

Front 32

Benxodiazepine effect on post=synaptic cell

Back 32

Increases Chloride conductance and hyperpolarizes the cell

Front 33

GABA antagonist mechanism

Back 33

competitively antagonize GABA BZD site, preventing hyperpolarization of the postsynaptic neuron, increasing transmission

Front 34

Of the behavior modifying drugs, _____ has anticholinergic effects while_____ does not.

Back 34

paroxetine - anticholinergic

fluoxetine - no anticholinergic

Front 35

Can be used with

Back 35

Tricyclic anti-depressant to decrease latency effect, reduce panic-like states, or reduce separation anxiety

Front 36

Diazepam uses

Back 36

dogs - behavior disorders - sedation/anxiolytic
Cats - treat urine spraying

Front 37

Diazepam adverse effects

Back 37

idiopathic hepatic necrosis in cats,

Front 38

Clorazepate

Back 38

metabolized in acidic stomach,to active metabolite before it is absorbed

Front 39

Clorazepate adverse effects

Back 39

excessive ataxia sedation

Front 40

Azapirones mechanism

Back 40

agonist at presynaptic and postsynaptic 5HT receptors(serotonin agonist)

Front 41

Azapirones side effects

Back 41

GI signs, alteration in social behavior,
Does not cause sedation or disinhibition phenomenon

Front 42

Tricyclic anti-depressants (TCA's) mechanism

Back 42

inhibit reputake of serotonin and NE
Alpha 1 antagonist

Front 43

TCA general effects

Back 43

moderate excessive arousal, reduce anxiety, enhance learning, maybe pain relief

Front 44

TCA metabolism

Back 44

metabolized by Cyp450 enzyme

Front 45

TCA contraindications:

Back 45

don't use with patients with glaucoma, or keratoconjuctivitis

Front 46

TCA's are effective starting

Back 46

in 2 -4 weeks

Front 47

MAOI's

Back 47

Selegiline

Front 48

Selegiline is used for

Back 48

canine cognitive disorder
canine pituitary dependent hyperadrenocorticocism

Front 49

Don't use MAOI's concurrently with

Back 49

TCA or SSRI's
leads to toxic levels of neurotransmitters

Front 50

Serotonin syndrome

Back 50

hypertension, hyperthermia, restlessness, tremor, seizures, altered mental status, possible death

Front 51

Benzodiazepines are modify behavior by

Back 51

sedative, tranquilization, anticonvulsant, adjunct to anesthesia,

Front 52

Benzodiazapine adverse effects

Back 52

Disinhibition in animals with fear-induced aggression
agitation, ataxia, muscle fasiciculation etc

Front 53

Benzodiazapine is metabolized in the

Back 53

liver

Front 54

Midazolam has __ the potentcy and _____ the affinity as diazepam

Back 54

twice
twice

Front 55

Lorazepam is used for

Back 55

status epilepticus
lasts longer than Diazepam and Midazolam

Front 56

Flumazenil is an

Back 56

antagonist to benzodiazepine
Used to counter act drop in blood pressure caused by benzodiazepine

Front 57

Flumazenil side effects

Back 57

arrhythmias, death
contraindications, patients with hypersensitivity to benzodiazepines/flumazenil