Be Chapter 7 Part 3

Front 1

Describe surface treatments using self-assembled monolayers?

Back 1

molecules are designed to be thermodynamically favorable to align on and form covalent bonds with surface of biomaterial

Front 2

What are common characteristics about self-assembling monolayers?

Back 2

they are amphiphilic
possess three key regions:
1) Attachment group
2) Assembling structure- long hydrocarbon chain
3) functional (polar) head group

Front 3

What role does the functional group play?

Back 3

can be used to alter hydrophobicity of substrate material
and can be a point of further chemical reaction- attachment of biologically active molecules

Front 4

What is the driving force for assembly?

Back 4

strong exothermic reaction between substrate and attachment group

Front 5

What are some commonly used attachment groups?

Back 5

silanes because they react readily with amines and hydroxyl groups
-materials with large amounts of hydroxyl groups like glass and metal oxides are preferred substrates, or they may be pretreated via plasma discharge to increase the number of appropriate reactive groups on the surface

Front 6

What role do the alkyl chains have?

Back 6

van der waals between non polar regions will cause crystallization

Front 7

What is required to assure that tight packing of attachment groups and alkyl chains is achieved?

Back 7

high molecular mobility of coating species

Front 8

What are some of the advantages of SAM

Back 8

1) Ease of formation
2) Chemical stability of coating
3) variety of chemical moieties that can be included either in the attachment or functional group

Front 9

What disadvantage is associated with SAM?

Back 9

need particular chemistries