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22 Cards in this Set

  • Front
  • Back
Buprenorphine
(partial opioid agonist) – opiate detoxification.
(subtex)
Or formulation containing buprenorphine and naloxone (suboxone) available for outpatient.
Greater safety of margin than methadone regarding safety margin
Tacrine
(Cognex)
Anticholinergic used for alzheimers
First line in treatment of neuroleptic induced parkinsonism and for acute dystonia
CNS muscarinic antagonists
s/e: blurry vision (cycloplegia), constipation, urinary retention, sedation and delirium
Galantamine
(reminyl)
Anticholinergic used for alzheimers
First line in treatment of neuroleptic induced parkinsonism and for acute dystonia
CNS muscarinic antagonists
s/e: blurry vision (cycloplegia), constipation, urinary retention, sedation and delirium
Rivastigmine
(exelon)
Anticholinergic used for alzheimers
First line in treatment of neuroleptic induced parkinsonism and for acute dystonia
CNS muscarinic antagonists
s/e: blurry vision (cycloplegia), constipation, urinary retention, sedation and delirium
Donepezil
(aricept)
Anticholinergic used for alzheimers
First line in treatment of neuroleptic induced parkinsonism and for acute dystonia
CNS muscarinic antagonists
s/e: blurry vision (cycloplegia), constipation, urinary retention, sedation and delirium
Selegiline
MAOI type B
Increases extracellular DA in the striatum
For parkinson dz/ parkinsonism/ dystonia
S/e: hypertensive crisis, arrhythmias, orthostatic HoTN, compulsive behaviors, hallucinations, EPS, dyskinesia
Avoid abrupt cessation
Duloxetine
CYMBALTA
Heterocyclic antidepressant – SNRIs
Inhibits NE and serotonin reuptake
MDD, GAD, DM neuropathy
s/e hepatotoxicity, seizures, SIAH, hyponatremia
Oxcarbazepine
Anticonvulsants
And for bipolar d/o
Blocks voltage-sensitive Na channels and stabilizes neural membranes, inhibits repetitive firing and decreases synaptic impulse propagation
Check Creatinine at baseline
Stevens-Johnson, thrombocytopenia, leukopenia, hyponatremia
topiramate
(topomax)
Anticonvulsants
Partial seizures, and Migraine HA
s/e: nephrolithiasis, metabolic acidosis, osteomalacia and osteoporosis
Benztropine
For parkinsonism and extrapyramidal rxns and dystonic rxns
Antagonizes acetylcholine and histamine receptors
s/e: tachycardia, psychosis (anticholinergic), dry mouth, constipation, urinary retention
Diphenylhydramine
Anxiolytic
Hypnotic/sleep med
Useful for extrapyramidal sx and short term insomnia
Nonselective antihistamine
s/e: hemolytic anemia, agranulocytosis, pancytopenia, constipation, blurred vision
Amantadine
For influenza, parkinsonism, extrapyramidal disorders
Potentiates CNS dopaminergic responses
Check Cr at baseline
Naltrexone
Mu opioid antagonist that is used to prevent alcohol relapse and to lessen the severity of relapse in pts with alcohol dependence.
Initiated once pt has been DETOXIFIED.
At least 1 wk after last opioid exposure otherwise can result in withdrawal.
Reduces alcohol craving.
Best when combined with psychosocial interventions.
Clonidine
CNS alpha 2 adrenoreceptor agonist. Presynaptic autoreceptor that inhibits release of CNS NE.
Primarily used as anti-HTN.
Decreases autonomic symptoms.
Treatment of ADHD and tourette’s syndrome may be useful for impulsiveness and other forms of behavioral dyscontrol.
s/e include sedation, dizziness and HoTN.
Methylphenidate
Ritalin
psychostimulant
ADHD, narcolepsy, and some forms of depression
Alteration of CNS monoamine function
Facilitating endogenous NT release
Labilities inducing tolerance and psychological dependence leading to abuse.
S/e sympathomimetic: tachy, insomnia, anxiety, HTN and diaphoresis.
Dexmethylphenidate
Dexedrine
A psychostimulant
ADHD, narcolepsy, and some forms of depression
Alteration of CNS monoamine function
Facilitating endogenous NT release
Labilities inducing tolerance and psychological dependence leading to abuse.
S/e sympathomimetic: tachy, insomnia, anxiety, HTN and diaphoresis.
D and L amphetamine
Adderall
psychostimulant
ADHD, narcolepsy, and some forms of depression
Alteration of CNS monoamine function
Facilitating endogenous NT release
Labilities inducing tolerance and psychological dependence leading to abuse.
S/e sympathomimetic: tachy, insomnia, anxiety, HTN and diaphoresis.
Atomoxetine
(Strattera)
ADHD
Selective NE reuptake inhibitor.
Propranolol
Anxiolytic
Beta blocker
Alter behavior and mood states by altering both CNS and peripheral catecholamine function.
Diminish central arousal
Peripherally reduce tachycardia, tremor, sweating and hyperventilation.
s/e: bradycardia, HoTN, asthma exacerbation and masking hypoglycemia.
Eszopiclone
LUNESTA
Hypnotic/sleep med
Interacts w/ GABA receptor complexes
s/e: withdrawal if abrupt, amnesia, hallucinations, aggressive behavior, dry mouth,
Ramelteon
ROZEREM
Hypnotic/sleep med
Binds to melatonin MT1 and MT2 receptors (agonist)
s/e: HA, nausea, diarrhea, dizziness, fatigue
Memantine
(namenda)
Antagonist at the excitatory glutamatergic NMDA receptor. Approved for moderate-to-severe dementia of Alzheimer type. Antagonism of the NMDA receptor may help prevent glutamate-mediated excitotoxicity and improve function of neurons in some forms of memory.