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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Step 1 of Glycolysis?
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Glucose + Hexokinase +ATP--> Glucose-6 phosphate +ADP
Reversible? Bypass Enzyme(s)? |
Reversible: NO
Bypass Enzyme: G-6-P'ase (on luminal surface of ER) |
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Step 2 of Glycolysis?
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Glucose-6 phosphate + Phosphoglucose Isomerase ---> Fructose-6 phosphate.
Reversible? Bypass Enzyme(s)? |
Reversible: Yes
Bypass Enzyme: N/A |
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Step 3 of Glycolysis?
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F6P + Phosphofructokinase-1(PFK-1) +ATP ---> Fructose-1,6 bisphosphate(F-1,6-bP) + ADP
Reversible:? Bypass Enzyme(s):? |
Reversible: NO
Bypass Enzyme(s): F-1,6-bisphosphatase |
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Step 4/5 of Glycolysis?
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F-1,6-bP + Fructose Bisphosphate Aldolase ----> dihydroxyacetone phosphate(DHAP) and glyceraldehyde 3-phosphate(G-3-P).
DHAP + Triose Phosphate Isomerase ---> G-3-P. |
Reversible: Yes
Bypass Enzyme(s): N/A |
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Step 6 of Glycolysis?
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G-3-P + G-3-P Dehydrogenase + NAD+ ---> 1,3-bisphosphoglycerate(1,3-BPG) + NADH
Reversible:? Bypass Enzyme(s):? |
Reversible: Yes
Bypass Enzyme: N/A |
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Step 7 of Glycolysis?
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1,3-BPG + Phosphoglycerate Kinase +ADP---> 3-Phosphoglycerate(3-PG) + ATP
Reversible:? Bypass Enzyme(s):? |
Reversible: Yes
Bypass Enzyme: N/A |
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Step 8 of Glycolysis?
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3-PG + Phosphoglycerate Mutase ----> 2-Phosphoglycerate(2-PG).
Reversible? Bypass Enzyme(s)? |
Reversible: Yes
Bypass Enzyme(s): N/A |
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Step 9 in Glycolysis?
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2-PG + Enolase -----> Phosphoenolpyruvate(PEP) + H2O
Reversible? Bypass Enzyme(s)? |
Reversible: Yes
Bypass Enzyme(s): N/A |
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Step 10 in Glycolysis?
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PEP + Pyruvate Kinase + ADP ---> Pyruvate + ATP
Reversible? Bypass reactions? |
Reversible: NO
Bypass Reactions: 1) Pyruvate + Pyruvate Carboxylase + ATP ---> Oxaloacetate + ADP. 2) Oxaloacetate + PEP Carboxykinase (PEPCK) + GTP ---> PEP + GDP. |
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Describe difference between hexokinase/glucokinase.
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? (Devlin pg 597)
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Which step yields reduced NADH in glycolysis?
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Step 6, conversion of G3P-->1,3-BPG
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Cori Cycle
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-Part of gluconeogenesis.
-Recycles lactic acid in both muscle and erythrocytes. -Prevents Lactic Acidosis Mechanism? |
Lactic acid travels through bloodstream to liver, where it's converted to glucose. Glucose is re-delivered to RBC's (for further glycolysis) and muscle, stored as glycogen, until epinephrine stimulates conversion to lactose.
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Why do RBC's always produce lactic acid from glycolysis?
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They don't have the ability to process Pyruvate in the TCA cycle (no mitochondria), so all the pyruvate goes to lactic acid.
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Importance of Gluconeogenesis?
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It's essential for blood glucose levels to be maintained even when dietary glucose and glycogen stores have been used up. However, glycogen is the body's first line of defense against hypoglycemia.
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