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10 Cards in this Set
- Front
- Back
What significant side effect can chloramphenicol cause in children?
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Grey Baby Syndrome - rapid, severe heart failure
Causes uncoupling of oxidative phosphorylation (ETC/Cell respiration) specifically in heart tissues causing shock, cyanosis, and death |
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What severe side effect is associated with PO Chloramphenicol?
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Bone marrow toxicity which can lead to irreversible, fatal aplastic anemia
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What should pts avoid when taking tetracyclines?
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Magnessium, Calcium, Aluminum, and Iron within two hours of taking meds b/c it severely decreases absorption
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What side effects can tetracycline cause?
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Tooth discoloration if permanent dentition is not already in place
Photosensitivity Pseudotumor cerebri (never give with isotretinoin, worry about it with obese, fertile women) |
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Why are aminoglycosides bacterioCIDAL when all other translation inhibitors (protein synth inhibitors) bacterioSTATIC?
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They block the very first step of protein synthesis causing misreading of mRNA
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What serious side effect can aminoglycosides cause?
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Ototoxicity - must monitor abx levels in the blood
Also nephrotoxic and neurotoxic |
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What is the DOC for pts requiring PCN who are allergic?
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Erythromycin
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Macrolides are notorious for drug interactions, but Erythromycin plus what other drug are of most concern? And what do they cause when used together?
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Anti-histamines (macrolides are often prescribed for URIs and pts will often use an anti-histamine to help make themselves more comfortable)
Cause significant QT prolongation resulting in Torsade de Pointe |
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What is the DOC for anaerobic infections above the diaphragm?
What is the DOC for anaerobic infections below the diaphragm? |
Clindamycin
Metronidazole |
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As a point of interest, what toxin is a protein synthesis inhibitor in eukaryotes (humans)?
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Diphtheria toxin
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