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10 Cards in this Set
- Front
- Back
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Gold
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prevents further damage by suppresses Macrophages
slows progression of bone and articular disease MOST EFFECTIVE AGENT FOR RHEUMATOID ARTHRITIS - only for CHRONIC Tx do NOT use if have kidney disease or liver disease. Adverse Rxn: dermatitis of the skin and mucus membranes, blue/greyish discoloration of skin. Overdose: Tx with dimercaprol |
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D-penicillamine
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MOA - Unknown
Use: Rheumatoid factor and chelates heavy metals, used to tx heavy metal poisoning. Adverse Rxns: severe! dermatitis, aplastic anemia, nephritis |
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Methotrexate
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Use: folic acid antagonist
MOA: inhibits dihydrofolate reductase Much lower doses are used to Tx rheumatoid arthtitis then cancer. Adverse Rxn: cyclopenia, esp leukopenia and megaloblastic anemia, most commonly mucosal ulceration and nausea. |
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Steroids
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inhibit phospholipase A2: prevent arachoadonic acid production and prevent prostaglandin production
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There are 5 Anti-tumor necrosis factor agents:?????
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Thalidomide
Pentoxyfilline Infliximab Etanercept Adalimumab |
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Thalidomide
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inhibits production and secretion of TNF
use is limited to leprosy, HIV, Mutiple Myeloma Extremely teratogenic --> DO NOT use in women of reproductive age! |
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Pentoxyfilline
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phosphodiesterase inhibitor
causes TNF secretion inhibition platelet aggregation inhibitor reduction of inflammatory states is limited to acute alcohol hepatitis |
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Inflixamab
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monoclonal Antibody
directed against TNF causes a reduction in TNF levels in the body Use: RA, ankylosing apondylitis, psoriatic arthritis, chon's disease, ulcerative colitis can increase risk of acute onset septic infection, increase risk of Tb and lymphomas, and MS |
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Etanercept
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administered subQ
recombinant TNF receptor Use: RA, ankylosing spondyltitis, psoriatic arthrotos, and juvenile RA |
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Adalimumab
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administered subQ
fully human monoclonal Ab directed against TNF Use: RA, psoriatic arthritis, ankylosing spondyltitis, Chron's disease NOT APPROVED FOR USE IN CHILDREN*** Adverse: aplastic anemia, thrombocytopenia, leukopenia, MS, |
