Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
Treatments used for ALL?
|
6-MP and actinomycin
|
|
|
Combination therapy for ALL?
|
Prednisone and vincristine
|
|
|
MOA of prednisone in the treatment of ALL
|
Prednisone is a steroid that induces lymphocytopenia
|
|
|
MOA of vincristine in treatment of ALL?
|
Binds to tubulin and blocks it from forming microtubules. Mitosis is therefore inhibited. This is classified as a mitosis inhibitor
|
|
|
AE of vincristine?
|
Peripheral neuropathy, phlebitis (vein inflammation), alopecia, and multiple GI problems
|
|
|
POMP stands for: prednisone, oncovin (vincristine), methotrexate, purimethol. What is this a treatment for and MOA of methotrexate and purimethol.
|
Treatment for ALL
Methotrexate: inhibits dihydrofolate reductase, inhibiting the use of folate and therefore the synthesis of DNA. Purimethol: another term for 6-MP. |
|
|
Purimethol (6-MP) side effects?
|
stomatitis, bone marrow suppression, alopecia, nausea, vomiting and renal and hepatic damage
|
|
|
ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) is used to treat what?
|
Hodgkin's lymphoma
|
|
|
MOA of bleomycin and adriamycin?
|
Destroy DNA by creating radical oxygen species
|
|
|
Dacarbazine MOA
|
alkylating agent, killing neoplastic cells by adding an alkyl group to their DNA. Highly emetogenic and potent bone marrow suppressor
|
|
|
Mechlorethamine
|
alkylating agent, alkylating guanines in DNA so that they cross-link in pairs or are removed.
AE: severe nausea and vomiting, extreme bone marrow suppression, herpes zoster, extensive blisters |
|
|
Procarbazine
|
inhibits both DNA and RNA synthesis.
bone marrow suppression, disulfiram reactions and neurotoxicity (drowsiness that progresses to hallucinations and paresthesias) |
