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10 Cards in this Set
- Front
- Back
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which patient population have incompletely developed tubular secretory mechanisms and thus often retain certain drugs that compete for renal transporters?
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neonates (<30 days) and preemies (>33wks)
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what drugs are competitive for PCT renal transporters?
What drugs are P450 inducers vs. inhibitors? |
competitive: sulfonamides, uric acid, probenacid, thiazides, salicylates, penicillins
inducers of P450: ETOH, barbituates, pheytoin, Rifampin,uric acid, ocp/birth control, L-dopa, methadone inhibitors of P450: sulfonamides, coumadin/dicumarol, phenybutazone, tolbuatmide, cimetidine, isoniazid, chloramphenicol **many* inhibitors of P450 are assumed to be "easily displaced by albumin" |
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easily displaced: "some proteins can spew"
inducible P450: "one pharmaceutical brings about rapid liver metabolism" inhbitory P450: "Some pharmacuetical classes inhibit drug catabolism" compettive: "some pharms plus urate stop transporters" |
easily displaced:
SULFONAMIDES, PHEHYLBUTAZONE, COUMADIN, SULFONYUREAS inducible: OCP, Phenytoin, barbituates, alcohol, rifampin, l dopa, methadone inhibitory: sulfonamides, probenacid, penicillin, urate, isoniazid, dicumarol, cimetidine transporters: sulfonamides, probenacid, pens, urate, salicylates, thiazides. |
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What do the following bad drug combos cause?
AG + LOOP DIURETICS MAOI + SSRI AMIODARONE + FLQ FLQ + CATIONIC AGENTS OR VIT C ETOH OR RIFAMPIN + ISONIAZID |
AG + LOOP -> NEPHROTOX AND OTOTOX
MAOI + SSRI -> SEROTONIN SYNDROME ANTIARTHYMICS + FLQ -> TORSADES, QT PROLONGATION CATIONS + FLQ -> IMPAIRED ABSORPTION OF FLQ ALCOHOL OR RIFAMPIN + ISONIAZID -> LIVER DAMAGE, FAILURE |
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drugs that cause BMT and nephotox and hepatotox?
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BMTox: chemo agents, chloramphenicol, ACT, guancycolvir, IFN, flucytosine, carbamazepine
nephro: AGs,foscarnet, cidofovir, NSAIDs, cyclosporine, amphotericin B, hepato: all imdazoles, IFN, nevirapine, HMG coA reductase inhibitors, valproic acid, isoniazid, carbemazepine |
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what can PDE 5 inhibitors cause adversely?
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NAION ( non arteritic - optic neuropathy)
ototox both are irreversible. |
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what can cause drug induced lupus?
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hydralazine
procanamide |
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what can lower the seizure threshold and lead to them?
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meperidine, bipropion
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what 2 drugs cause hepatotox and neural tube defects in prego moms?
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valproic acid
carbamezepine |
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first line for cryptococcal meningitis and what about for meningococcal meningitis?
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cryptococcal: flucytosine
meningococcal: rifampin |
