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10 Cards in this Set
- Front
- Back
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DSM-IV of Schizophrenia
1. Symptoms 2. Dysfunction 3. Duration |
1. Symptoms >1-2 months
-delusions -hallucinations -disorganized speech -disorganized behavior -negative symptoms 2. Social/occupational dysfunction 3. prodrome/acute/residual symptoms for >6 months |
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Incidence of Schizoprenia
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.5% in rural areas
2.5% in urban areas Same across different cultures |
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Neurobiology of Schizophrenia
1. 4 Locations 5. Neurotransmitter involved |
Limbic areas
1. cingulate gyrus 2. septal area 3. hippocampus/amygdala 4. orbitofrontal areas |
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Onset of Schizophrenia
1. Age 2. Prodrome |
1. 15-35
2. Abrupt: better outcome Insiduous: worse outcome |
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4 Positive Symptoms in Schizophrenia
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1. Delusions: persecution, grandiosity, ideas of reference, thought insertion
2. Hallucinations: auditory are most common 3. Abnormal behavior: stereotypical; bizarre; agitation 4. Thought disorder: vague speech, neologisms, clanging, echolalia, Wernicke's-like |
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2 Negative Symptoms in Schizophrenia
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1. Disturbed affect
2. Alogia (disturbed speech) |
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4 indicators of good outcome in Schizophrenia
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1. later and abrupt onset
2. level of pre-morbid functioning 3. prominent affective symptoms or disorganized behavior 4. Paucity of negative symptoms |
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The 4 subtypes of schizophrenia
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1. Paranoid: prominent delusions/hallucinations, little disorganization, catatonia, flat affect. Usually abrupt onset and has best outcome
2. Disorganized: disorganized behavior and speech, flat or inappropriate affect 3. Catatonic: abnormal motoric/posturing or speech (echolalia) 4. Undifferentiated |
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3 pathways targeted by antipsychotics
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Dopaminergic transmission from the brainstem to the basal ganglia, frontal, and temporal lobes
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Difference between Typical and Atypical antipsychotics
1. effect on pathways 2. improvement of depression 3. improvement of negative symptoms |
1. Typical give more basal ganglia/EPS side effects
2. Atypicals work better on the depression 3. Neither work well (atypicals possibly slightly better) |
