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10 Cards in this Set

  • Front
  • Back
DSM-IV of Schizophrenia
1. Symptoms
2. Dysfunction
3. Duration
1. Symptoms >1-2 months
-disorganized speech
-disorganized behavior
-negative symptoms

2. Social/occupational dysfunction

3. prodrome/acute/residual symptoms for >6 months
Incidence of Schizoprenia
.5% in rural areas
2.5% in urban areas

Same across different cultures
Neurobiology of Schizophrenia
1. 4 Locations
5. Neurotransmitter involved
Limbic areas
1. cingulate gyrus
2. septal area
3. hippocampus/amygdala
4. orbitofrontal areas
Onset of Schizophrenia
1. Age
2. Prodrome
1. 15-35

2. Abrupt: better outcome
Insiduous: worse outcome
4 Positive Symptoms in Schizophrenia
1. Delusions: persecution, grandiosity, ideas of reference, thought insertion

2. Hallucinations: auditory are most common

3. Abnormal behavior: stereotypical; bizarre; agitation

4. Thought disorder: vague speech, neologisms, clanging, echolalia, Wernicke's-like
2 Negative Symptoms in Schizophrenia
1. Disturbed affect

2. Alogia (disturbed speech)
4 indicators of good outcome in Schizophrenia
1. later and abrupt onset
2. level of pre-morbid functioning
3. prominent affective symptoms or disorganized behavior
4. Paucity of negative symptoms
The 4 subtypes of schizophrenia
1. Paranoid: prominent delusions/hallucinations, little disorganization, catatonia, flat affect. Usually abrupt onset and has best outcome

2. Disorganized: disorganized behavior and speech, flat or inappropriate affect

3. Catatonic: abnormal motoric/posturing or speech (echolalia)

4. Undifferentiated
3 pathways targeted by antipsychotics
Dopaminergic transmission from the brainstem to the basal ganglia, frontal, and temporal lobes
Difference between Typical and Atypical antipsychotics
1. effect on pathways
2. improvement of depression
3. improvement of negative symptoms
1. Typical give more basal ganglia/EPS side effects

2. Atypicals work better on the depression

3. Neither work well (atypicals possibly slightly better)