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9 Cards in this Set

  • Front
  • Back
2 major metabolites of THC
OH-THC: active, plasma levels peak earlier

THC-COOH: inactive, plasma levels peak later

??levo isomer is more active??
Absorption, Metabolism, Distribution, and Elimination
1. Psychotropic Threshold
2. Plasma levels
3. Metabolism
4. Distribution
5. Elimination
1. psychotropic threshold >25 ng/ml

2. Drop to <2 ng/ml in 4 hours

3. Lipophilic: distributed into fatty tissues

4. cyt P450

5. 35% urine, 65% feces
Marijuana use detection
-Urine Test
1. Sensitivity
2. Window for use
3. Relation to plasma levels

4. Plasma Test
1. Sensitive to 50 ng/ml, but cannot distinguish between THC or metabolites

2. single joint will test positive for 8-96 hours

3. Can have positive urine test for inactive metabolite long after active metabolite is gone.

4. Plasma samples correlate to time and amount used
Synthetic Cannabinoid Agonist
1. Name
2. 2 FDA approved uses
1. Dronabinol
2. Nausea from chemotherapy and AIDS-related wasting
Cannabinoid receptor distribution
1. CB1
2. CB2
1. BRAIN, fat, liver, duodenum, muscle

2. LYMPHOCYTES > macrophages > cytokines
1. Receptor preference
2. Name, abundance, and potency
1. Bind CB1>CB2

-Annandamide: less abundant, more potent
-2-Arachidonoyl glycerol: more abundant, less potent
CB1 receptors in the CNS
1. 6 dense areas
2. 3 moderate areas
1. Dense: basal ganglia, cerebellum, hippocampus, NAcc, Middle prefrontal cortex, and parietal cortex

2. amygdala, spinal cord, and brainstem
Endocannabinoid Signalling
1. Name for the mechanism
2. Site of release
3. Site of action
4. Cellular response
1. DISP: Depolarization-Induced Suppression of Inhibition

2. Postynaptic release upon stimulation

3. Presynaptic binding inhibits GABA and glutamate release (inhibitory nts.)

4. G Protein leads to decreased cAMP levels and other downstream effects
CB1 Anatagonists
2/3.Potential therapeutic uses
1. Rimonabant

2. Block direct reinforcing effects of drugs and food

3. Block motivational effects